The effects on facility of outflow of lens depression (controlled mechanical retrodisplacement of the crystalline lens to simulate cyclotonia in excised eye preparations), prolonged perfusion, and intracameral hyaluronidase were evaluated in 16 pairs of freshly excised canine eyes. Lens depression increased facility of aqueous outflow by an amount greater than could be attributed to mechanical ...

In recent papers (1, 5) it was suggested that invasion of the adjacent normal tissues by malignant tumors may be facilitated by the presence of a spreading fac,tor such as hyaluronidase. In support of this hypothesis, it was reported that some human carcinomas have been found to contain a sprcading factor. Further support would bc given to this hypothesis if it could be shown that invasiveness ...

Recently we purified to homogeneity hyaluronidase from stonefish (Synanceja horrida) venom, for the first time from a marine source [Poh, Yuen, Chung & Khoo (1992) Comp. Biochem. Physiol., in the press]. In the present study the reaction products of the hyaluronidase purified from stonefish venom were analysed. It produced tetra-, hexa-, octa- and deca-saccharides as major end products, but not...

Different workers have at various times sought to correlate the in vivo and in vitro activities of hyaluronidase preparations. Chain & Duthie (1940), drawing attention to the association between diffusion in the tissues and the mucolytic activity of testicular extracts, pointed out that the viscosityreducing and diffusing activities of various enzyme preparations were in good agreement. McClean...

BACKGROUND Hyaluronidases have been found as the target enzymes in the development of osteoarthritis (OA) disease. While there is still no curative treatment for this disease, recent studies on the treatment of OA were focused on the effectiveness of natural products which are expected to improve the symptoms with minimal side effects. The aim of this study was to screen selected Malaysian plan...

Vascular endothelium is covered with an extensive mesh of glycocalyx constituents, which acts like an effective barrier up to several micrometers thick that shields the luminal surface of the vasculature from direct exposure to flowing blood. Many studies report that various enzymatic and pharmaceutical challenges are able to increase glycocalyx porosity, resulting in farther permeation of plas...

In summary, hyaluronidase augmented SCRT is becoming an accepted alternative for children with mild to moderate dehydration when ORT has failed and intravenous access is difficult. While use of a nasogastric tube is an accepted alternative, this technique is invasive and usually requires restraining of the child's extremities and can lead to complications. The use of oral ondansetron has enhanc...

SUMMARY It has been demonstrated that solid hepatoma lysosomes lack hyaluronidase activity, whereas normal rat liver lyso somes contain a high level of this enzyme. This result was also found with lysosomes from an ascites hepatoma, Walker carcinoma 256, and virally transformed BHK cells. In contrast, 0-yV-acetylglucosaminidase activity was shown to be present in lysosomes from tumor cells, alt...