BACKGROUND Nephrotoxicity is characterized and scored by many parameters such as vacuolization, dilatation, hyaline cast, debris or degeneration in injured renal tissue. In this short report, we attempt to find, the most correlated parameters with kidney tissue pathology damage score (PDS) in Cisplatin-induced nephrotoxicity. METHOD A total of 207 normal and toxic rats' kidney tissue (induced...

There are several points of interest about hyaline membrane disease in relation to any discussion of fibrinolytic activity. In paediatrics hyaline membrane disease is a persisting cause of mortality. Between 40% and 60% of premature infants dying in the first five days of life are said to die of this condition. The diagnosis falls to the pathologist who examines the lungs after death, for durin...

Repair of cartilage injury with hyaline cartilage continues to be a challenging clinical problem. Because of the limited number of chondrocytes in vivo, coupled with in vitro de-differentiation of chondrocytes into fibrochondrocytes, which secrete type I collagen and have an altered matrix architecture and mechanical function, there is a need for a novel cell source that produces hyaline cartil...

BACKGROUND Hyaline ring granuloma (HRG) of the oral cavity is an uncommon disorder considered to be a foreign-body reaction resulting from implantation of food vegetable particles. Microscopically, it is characterized by the presence of structures of hyaline rings in an inflamed fibrous tissue background, which contains multinucleated giant cells. MATERIAL AND METHODS We present the case of a...

OBJECTIVE To assess long-term outcomes of osteocartilaginous transplantation for non-degenerative lesions of hyaline articular cartilage in the knee, by performing minibiopsies from the transplanted area and examining them histopathologically. PATIENTS AND METHODS Forty-four patients with post-traumatic cartilage injuries of the bearing surfaces of the knee were enrolled in a prospective stud...

The aim of this study was to carry out a histomorphometric analysis of calcified cartilage zone (CCZ) and its interfaces between hyaline cartilage and subchondral bone. The study used 40 donated normal human femoral condyles, from which paraffin-embedded sections were prepared after fixation and decalcification. The histomorphology of the CCZ were qualitatively and quantitatively observed by st...

Hyaline cartilage is a strong durable material that lubricates joint movement. Due to its avascular structure, cartilage has a poor self-healing ability, thus, a challenge in joint recovery. When severely damaged, cartilage may need to be replaced. However, currently we are unable to replicate the hyaline cartilage, and as such, alternative materials with considerably different properties are u...

Carbon dioxide (CO2) exposure was found to result in production of pulmonary hyaline membranes in rodents by a number of investigators (1-3). In previous studies with Niemoeller (4), we were able to show that incidence of hyaline membrane formation progressively decreases in guinea pigs during prolonged exposure to CO2 after compensation of the respiratory acidosis, suggesting a nonspecific aci...

Marrow stimulation is frequently employed to treat focal chondral defects of the knee. However, marrow stimulation typically results in fibrocartilage repair tissue rather than healthy hyaline cartilage, which, over time, predisposes the repair to failure. Recently, a cryopreserved viable chondral allograft was developed to augment marrow stimulation. The chondral allograft is comprised of nati...

Sir, Castleman’s disease, also known as Angiofollicular lymphnode hyperplasia is a rare disorder of lymphoreticular system with heterogenous clinical manifestations.1 Histopathologically, it has two variants1 hyaline vascular variant and plasma cell variant. While hyaline vascular variant usually present with localized yet marked lymphadenopathy2 with few constitutional symptoms, lymphoreticula...