نتایج جستجو برای: humanin peptide
تعداد نتایج: 158935 فیلتر نتایج به سال:
use of brain natriuretic peptide in predicting severity of respiratory distress syndrome in neonates
objective: animal studies show that vaccination with epitope-based peptides results in protective immunity. however, immunodominance should be regarded as a major challenge in this area. considering the advantages of epitopic-vaccines against hepatitis c virus (hcv) infection, herein, we compared the occurrence of immunodominance following mice immunization with three different hcv epitopic-pep...
objective: we introduce an rgd (arg-gly-asp)-containing peptide of collagen iv origin that possesses potent cell adhesion and proliferation properties. materials and methods: in this experimental study, the peptide was immobilized on an electrospun nanofibrous polycaprolactone/gelatin (pcl/gel) hybrid scaffold by a chemical bonding approach to improve cell adhesion properties of the scaffold. a...
Background and purpose: Antimicrobial peptides (AMP) are one of the most diverse antimicrobial compounds that have received much attention due to the development of drug resistance of pathogens to conventional antibiotics. But, few studies have evaluated anti-parasitic properties of AMP. The present study was conducted to compare the effect of a cecropin–melittin chimeric peptide (CM11) and met...
Brain-Derived Neurotrophic Factor (BDNF) is a neuroprotectant candidate for neurodegenerative diseases. However, there are several clinical concerns about its therapeutic applications. In the current study, we selected BDNF-mimicking small peptides from phage-displayed peptide library as alternative molecules to the clinical challenges. The peptide library was screened against BDNF receptor (Ne...
Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia
Introduction: Bombesin is a 14-aminoacid peptide isolated from frog skin. The mammalian counterparts of the frog peptide are neuromedin B (NMB) and gastrin-releasing peptide (GRP). Bombesin (BBN) is a peptide showing high affinity for the gastrin releasing peptide receptor (GRPr). Prostate, small cell lung cancer, breast, gastric, and colon cancers are known to over...
Interferon is a protein secreted by eucaryotic cells following stimulation by viruses, bacteria, and many other immunogenes. Recent medical studies indicate that interferons have effective role in the treatment of virus infections, immunodeficiency and certain types of cancer such as hairy cell leukaemia (HCL). The aim of the present study is to apply yeast strain for secreting human IFNα2b fol...
design of a novel metal binding peptide by molecular dynamics simulation to sequester cu and zn ions
heavy metal toxicity has serious adverse effects on the environment. the metal sequestering characteristics of a novel metal binding peptide (glu-cys) 11 gly+linker+hexahistidine (ec 11 :his 6 ) was investigated to determine if it can absorb cu 2+ or zn 2+ cations. molecular dynamics simulations were carried out using a model of 6 cu 2+ or zn 2+ and other ions enclosed in a fully hydrated simul...
phage-displayed random peptide libraries (rpl) provide a powerful technique for identification, structural and functional analysis of ligands for many different target molecules, including, antibodies, receptors or other proteins. this strategy has been verified to be an effective tool for research in immunology and successfully has been used to determine the target sequence for monoclonal and ...
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