نتایج جستجو برای: human neuronal sh sy5y cells

تعداد نتایج: 2699395  

Journal: :Pharmaceuticals 2023

In Alzheimer’s disease (AD), microglia, brain resident immune cells, become chronically inflammatory and neurotoxic. recent years, neuroinflammation has attracted particular interest in the scientific community. The genetic variants of molecules associated with ‘‘microgliopathies’’, including triggering receptor expressed myeloid cells-2 (TREM2), result increased risk developing AD cognitive de...

2011
Yu-Tzu Shih Ing-Jun Chen Yang-Chang Wu Yi-Ching Lo

San-Huang-Xie-Xin-Tang (SHXT), composed of Coptidis rhizoma, Scutellariae radix and Rhei rhizoma, is a traditional Chinese herbal medicine used to treat gastritis, gastric bleeding and peptic ulcers. This study investigated the neuroprotective effects of SHXT on microglia-mediated neurotoxicity using co-cultured lipopolysaccharide (LPS)-activated microglia-like BV-2 cells with neuroblastoma SH-...

Journal: :Protein and peptide letters 2006
XingSheng Wang DongLiang Wang Jing Zhao MeiHua Qu XiaoHong Zhou HaiJin He RongQiao He

Neuronal tau, through its proline-rich domain and the microtubule binding domain, binds to RNA non-sequence-specifically via electrostatic interaction. This binding inhibits the activity of tau. Tau and RNA were also found to co-localize in SH-SY5Y cells suggesting that RNA has opportunities to interact with tau in cells.

Journal: :Human molecular genetics 2012
Ghiabe-Henri Guibinga Gorjan Hrustanovic Kathryn Bouic Hyder A Jinnah Theodore Friedmann

Mutations in the gene encoding the purine biosynthetic enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) cause the intractable neurodevelopmental Lesch-Nyhan disease (LND) associated with aberrant development of brain dopamine pathways. In the current study, we have identified an increased expression of the microRNA miR181a in HPRT-deficient human dopaminergic SH-SY5Y neuroblastoma c...

2016
Aleksander Rust Charlotte Leese Thomas Binz Bazbek Davletov

Neuroblastomas constitute a major cause of cancer-related deaths in young children. In recent years, a number of translation-inhibiting enzymes have been evaluated for killing neuroblastoma cells. Here we investigated the potential vulnerability of human neuroblastoma cells to protease activity derived from botulinum neurotoxin type C. We show that following retinoic acid treatment, human neuro...

2013
João Barbosa Martins Maria de Lourdes Bastos Félix Carvalho João Paulo Capela

Paraquat (PQ), a cationic nonselective bipyridyl herbicide, has been used as neurotoxicant to modulate Parkinson's disease in laboratory settings. Other compounds like rotenone (ROT), a pesticide, and 1-methyl-4-phenylpyridinium ion (MPP(+)) have been widely used as neurotoxicants. We compared the toxicity of these three neurotoxicants using differentiated dopaminergic SH-SY5Y human cells, aimi...

Journal: :Scientific reports 2016
Lijun Zhong Juntuo Zhou Xi Chen Yaxin Lou Dan Liu Xiajuan Zou Bin Yang Yuxin Yin Yan Pan

B12 belongs to the coumarin class of compounds that have been shown to have various physiological and pharmacological activities including anti-inflammatory, antibacterial, and antioxidant. In the present study, we characterised the neuroprotective effects of B12 against H2O2-induced neuronal cell damage in SH-SY5Y cells. Protein expression profiling in combination with pathway analysis was dep...

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