Patients with type 1 diabetes mellitus and end-stage renal disease may remain on dialysis or undergo cadaveric kidney transplantation, living kidney transplantation, sequential pancreas after living kidney transplantation, or simultaneous pancreas-kidney transplantation. It is unclear which of these options is most effective. The objective of this study was to determine the optimal treatment st...

One third of healthy willing living kidney donors are rejected due to ABO blood group incompatibility and donor specific antibody. This increases pre-transplant dialysis duration leading to increased morbidity and mortality on the kidney transplantation waiting list. Over the last decade kidney paired donation is most rapidly increased source of living kidney donors. In a kidney transplantation...

Background & Aims: Renal transplantation is the best therapeutic option for End Stage Renal Disease (ESRD). The aim of this study was to determine the graft survival rate of renal transplantation in patients who have been transplanted from live donor in Shiraz Transplant Research Center, Shiraz, Iran. Methods: In a survival analysis study, organ survival rate after kidney transplantation from...

The kidney is vulnerable to injury, both acute and chronic from a variety of immune and metabolic insults, all of which at least to some degree involve inflammation. Regulatory T cells modulate systemic autoimmune and allogenic responses in glomerulonephritis and transplantation. Intrarenal regulatory T cells (Tregs), including those recruited to the kidney, have suppressive effects on both ada...

PURPOSE The number of patients waiting for kidney transplantation is incessantly increasing, but the number of cadaveric kidney transplantations or ABO-compatible donors is so insufficient that ABO-incompatible kidney transplantation is being performed as an alternative. There are overseas studies and research showing that the 5-year survival rate and 5-year graft survival rate of ABO-incompati...

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Abstract Background and Aims Renal ischemia-reperfusion injury is associated with delayed graft function poor long-term survival following transplantation. Linaclotide a guanylate cyclase C (GC-C) receptor agonist that increases intracellular cGMP concentrations promotes intestinal transport capacity by activating the GC-C receptor. Since CKD deficiency of in kidney, increasing kidney linacloti...

Neurologic and psychologic complications are usually related to drug toxicity, infections or symptoms induced by deterioration of renal allograft function. Metabolic encephalopathy, hypertensive encephalopathy, cerebrovascular events, and new-onset seizures have all been reported in organ-transplant recipients. Infections can be caused by listeria, cryptococcus, nocardia, aspergillus and mu...

Tacrolimus is a main drug for induction and maintenance immunosuppression for patients with kidney transplants in many centers. One of important side effect of drug is post-transplant diabetes mellitus. Of course, diabetes ketoacidosis (DKA) is rare. In this report, a 12-year-old girl with DKA was presented after 45 days of kidney transplantation.