There are 10× more bacterial cells in our bodies from the microbiome than human cells. Viral DNA is known to integrate in the human genome, but the integration of bacterial DNA has not been described. Using publicly available sequence data from the human genome project, the 1000 Genomes Project, and The Cancer Genome Atlas (TCGA), we examined bacterial DNA integration into the human somatic gen...

dna sequence determination is a tremendous human achievement. dna sequencing includes several methods and technologies in use for determining the order of the nucleotide bases (adenine, guanine, cytosine, and thymine) in a molecule of dna. knowledge of dna sequences has become indispensable for basic biological research, other research branches utilizing dna sequencing, and in numerous applied ...

At the June 26, 2000 Human Genome Announcement Speech at the White House, President Clinton praised the completion of the initial working draft sequence of the entire 3.2-Gb haploid human genome, stating: “It will revolutionize the diagnosis, prevention and treatment of most, if not all, human diseases.” The announcement was universally hailed as a historic achievement for some hopes for gallop...

The Human Genome Project (HGP) has provided a large amount of sequence information about the human genome. One type of sequence information obtained relates to expressed sequence tags (ESTs), i.e. partial DNA sequences of expressed genes. These ESTs are usually between 300 and 500 nucleotides in length. In many cases the sequence is unique to a degree that allows the identification of the corre...

Contact Information.........................4 T deluge of data and related technologies generated by the Human Genome Project (HGP) and other genomic research presents a broad array of commercial opportunities. Seemingly limitless applications cross boundaries from medicine and food to energy and environmental resources, and predictions are that life sciences may become the largest sector in th...

The goal of the 1000 Genomes Consortium is to characterize human genome structural variation (SV), including forms of copy number variations such as deletions, duplications, and insertions. Mobile element insertions, particularly Alu elements, are major contributors to genomic SV among humans. During the pilot phase of the project we experimentally validated 645 (611 intergenic and 34 exon targ...

The recent development of induced pluripotent stem (iPS) cell technology brings cell and gene therapies to patients one large step closer to reality. Technical improvements in various research fields sometimes come together fortuitously, leading to approaches to treating disease. If iPS cell technology continues to progress smoothly as expected and is actually applied to patients, the next logi...

Dr. Slosar is director, ethics. Ascension Health, St. Louis. I 'essica Blasko's review of genomic neurology clearly illustrates one of the most immediate consequences of the completion of the Human Genome Project (HGP). The HGP .ias resulted in a steady stream of new information and an exponential growth in the understanding of disease and its genetic basis. As Blasko notes, this increase in ou...

As the Human Genome Project (HGP) moves toward its successful completion, an increasing number of individuals are becoming interested in understanding this project and its results. Since the HGP has potentially significant ethical, legal, and social implications for all citizens, the number of individuals who do, or should wish to become familiar with the project is very high. In addition to it...

Epigenetics is one of the key areas of future research that can elucidate how genomes work. It combines genetics and the environment to address complex biological systems such as the plasticity of our genome. While all nucleated human cells carry the same genome, they express different genes at different times. Much of this is governed by epigenetic changes resulting in differential methylation...