INTRODUCTION The rate of intravenous thrombolysis with tissue-type plasminogen activator or urokinase for stroke patients is extremely low in China. It has been demonstrated that a telestroke service may help to increase the rate of intravenous thrombolysis and improve stroke care quality in local hospitals. The aim of this study, also called the Acute Stroke Advancing Program, is to evaluate t...

This paper presents a bi-objective capacitated hub arc location problem with single assignment for designing a metro network with an elastic demand. In the literature, it is widely supposed that the network created with the hub nodes is complete. In this paper, this assumption is relaxed. Moreover, in most hub location problems, the demand is assumed to be static and independent of the location...

BACKGROUND AND PURPOSE Enrollment into acute stroke clinical trials is limited to experienced tertiary centers with emergency research infrastructure. Feasibility of remote enrollment via telemedicine into an acute thrombolytic clinical trial has never been demonstrated. METHODS Using telemedicine, our hub stroke research center partnered with two spoke community hospitals to jointly particip...

Coordinated variation among positions in amino acid sequence alignments can reveal genetic dependencies at noncontiguous positions, but methods to assess these interactions are incompletely developed. Previously, we found genome-wide networks of covarying residue positions in the hepatitis C virus genome (R. Aurora, M. J. Donlin, N. A. Cannon, and J. E. Tavis, J. Clin. Invest. 119:225-236, 2009...

OBJECTIVE We analysed the integrated planning model adopted by the Italian region Emilia Romagna in year 2000 to cover the entire range of treatment of cardiovascular disease. This model, called "hub and spoke", provides for the transfer of patient care and treatment from peripheral units (the spokes) to central units (the hubs) once a certain complexity threshold has been reached. METHODS We...

Two competitors, a Leader and a Follower, are sequentially creating their hub and spoke networks to attract customers in a market where prices have fixed markups. Each competitor wants to maximize his profit, rather than a market share. Demand is split according to the logit model. The goal is to find the optimal hub and spoke topology for the Leader. We represent this Stackelberg game as a non...

Consider networks on n vertices at average density 1 per unit area. We seek a network that minimizes total length subject to some constraint on journey times, averaged over sourcedestination pairs. Suppose journey times depend on both route-length and number of hops. Then for the constraint corresponding to an average of 3 hops, the length of the optimal network scales as n13/10. Alternatively,...

Many transport service providers operate on hub-and-spoke network structures. Major operators may have several dedicated hub facilities that are leased for a time horizon rather than being owned or constructed. For a given discrete planning horizon, service providers must decide on the location of the hub ports (i.e. terminals), the period when the lease contract starts, the period when the exi...