نتایج جستجو برای: htlv 1 proviral load
تعداد نتایج: 2872681 فیلتر نتایج به سال:
BACKGROUND HTLV-1 infection is endemic among people of Melanesian descent in Papua New Guinea, the Solomon Islands and Vanuatu. Molecular studies reveal that these Melanesian strains belong to the highly divergent HTLV-1c subtype. In Australia, HTLV-1 is also endemic among the Indigenous people of central Australia; however, the molecular epidemiology of HTLV-1 infection in this population rema...
We read with interest the recent article by Pennington et al. 1 Based on the ability to detect Tax DNA in the blood of asymptomatic carriers with proviral loads exceeding 10 8 DNA copies/L, the authors conclude that leukocyte depletion (LD) may not provide complete protection from human T-cell leukemia virus–I (HTLV-I) transmission by transfusion. Lau et al 2 proved that cytomegalovirus (CMV)–i...
Human T-cell leukemia virus type 1 (HTLV-1) is a delta-type retrovirus that induces malignant and inflammatory diseases during its long persistence in vivo. HTLV-1 can infect various kinds of cells; however, HTLV-1 provirus is predominantly found in peripheral CD4 T cells in vivo. Here we find that TCF1 and LEF1, two Wnt transcription factors that are specifically expressed in T cells, inhibit ...
BACKGROUND The Interleukin 28B (IL28B) rs12979860 polymorphisms was recently reported to be associated with the human T-cell leukemia virus type 1 (HTLV-1) proviral load (PvL) and the development of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). METHODS In an attempt to examine this hypothesis, we assessed the association of the rs12979860 genotypes with HTLV-1 PvL l...
Human T-lymphotropic virus type 1 (HTLV-1) is a human retrovirus related to the chronic neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). CD4(+) T cells activation appears to play a key role on HTLV-1 infection. Here we investigated the expression of genes associated to T cell activation CD3e molecule, epsilon (CD3ɛ), lymphocyte-specific protein tyro...
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