نتایج جستجو برای: hsp72
تعداد نتایج: 2797 فیلتر نتایج به سال:
Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a population of immature myeloid cells with the ability to suppress T cell activation. They accumulate in tumor-bearing mice and humans and have been shown to contribute to cancer development. Here, we have isolated tumor-derived exosomes (TDEs) from mouse cell lines and shown that an interaction between TDE-ass...
Heat shock proteins (HSPs) are involved in tumour immunity, and are correlated with survival and drug resistance in numerous types of cancer. The present study investigated the expression of HSPs and multiple drug resistance (MDR) in human chondrosarcoma. HSP and P-glycoprotein (the MDR1 gene product) expression was evaluated by immunohistochemical analysis of paraffin-embedded sections obtaine...
The inducible 72 kDa heat shock protein (HSP72) has been shown to be protective in non-neuronal cells and neurons in culture, but its function and the control of its expression in the CNS are poorly understood. Although HSP72 is induced in neurons in vivo by neurotoxic compounds that produce seizures and neuronal damage, it is unknown if its expression is a specific response to excitation per s...
The aim of this study was to determine whether short-term heat acclimation (STHA) could confer increased cellular tolerance to acute hypoxic exercise in humans as determined via monocyte HSP72 (mHSP72) expression. Sixteen males were separated into two matched groups. The STHA group completed 3 days of exercise heat acclimation; 60 minutes cycling at 50% V̇O2peak in 40°C 20% relative humidity (RH...
The current study was done to look at a possible role of heat shock proteins (HSPs) in hypersensitivity pneumonitis (HP). The specific aims were to determine whether there was a difference in the expression of HSP72 in alveolar macrophages (AMs) between mice challenged with HP antigen and saline-treated control mice and between AMs obtained by bronchoalveolar lavage from 18 patients with HP and...
The contribution of heat shock protein 72 (HSP72) to the protection of cardiac function was examined in rats with chronic heat failure (CHF) following coronary artery ligation (CAL). The CAL animals revealed functional deterioration without low cardiac output 2 wk after CAL and with low cardiac output 8 wk after CAL, suggesting that CHF had developed by 8 wk after CAL. The hearts isolated from ...
background: the aim of this study is to create an ex vivo model to examine the expression of two heat shock protein 70 (hsp70) family members, heat shock protein 72 (hsp72) and heat shock constitute protein 70 (hsc70), at the mrna and protein levels in differentiating corneal cells from air exposed limbal stem cells. materials and methods: limbal biopsies were cultured as explants on a cellular...
زمینه وهدف: پروتئین شوک گرمایی 72( hsp72) و ظرفیت آنتی اکسیدانی تام (tac) دو شاخص مهم در دفاع درونی بدن می باشند. هدف از تحقیق حاضر بررسی تأثیر یک جلسه فعالیت ورزشی تداومی روی نوارگردان بر میزان hsp72 و tac پلاسمای موش های دیابتی شده توسط استرپتوزوتوسین بود. روش تحقیق: بدین منظور 40 سر موش صحرایی نر نژاد ویستار به وزن 165±1 گرم و سن 6 تا8 هفته، به طور تصادفی در 4 گروه (هر گروه 10 سر)، کنترل ...
مقدمه و هدف: پروتئین های شوک گرمایی (hsp) به توانایی سلول ها برای حفظ ساختار خود در برابر استرس های متفاوت کمک می کنند. هدف از این مطالعه بررسی تاثیر یک جلسه فعالیت ورزشی هوازی تداومی و تناوبی بر پاسخ hsp72،کورتیزول و کراتین کیناز (ck) خون بود. روش کار: این مطالعه از نوع نیمه تجربی بود که در آن 21 دانشجوی پسر ورزشکار به سه گروه برابر تداومی، تناوبی و کنترل تقسیم شدند. پروتکل فعالیت گروه تداومی ...
BACKGROUND To test the hypothesis that the heat shock response is associated with improved myocardial salvage after myocardial ischemia and reperfusion, rats treated with prior whole-body hyperthermia and 24 hours of recovery (n = 26) or 20 minutes of ischemic pretreatment and 8 hours of recovery (n = 24) and control rats (n = 27, n = 24, for hyperthermic and ischemic pretreatment, respectively...
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