The aim of the present study was to evaluate the Analgesic & anti inflammatory activities of the Momordica charantia extract. Momordica chirantia (MC) is a herbal medicine traditionally applied to treat so many diseases and disorders. In the evaluation of analgesic activity the model used was Eddy’s hot plate method in which the animals treated with Momordica charantia and standard Pentazocin h...

Adaptability is probably the most distinct characteristics of life which may be defined as sum of all nonspecific response of the body to any demands made upon it; fundamentally it was a physiological response; primary object of which was to maintain life and to re-establish the normal state. Analgesic and Immunomodulator activity of leaves of Artocarpus heterophyllus Lam. was evaluated by usin...

In this study a possible relationship between regulatory mechanisms involved in pain and blood pressure control has been investigated in the rat. Spontaneously hypertensive rats (SHR), their normotensive Wistar-Kyoto (WKY) controls, and two experimental models of hypertension together with their appropriate sham-operated controls were tested for their responsiveness to pain. Two methods for mea...

The present study was carried out to investigate the analgesic activity of Etoricoxib (10 mg) for individual drug therapy and etoricoxib (5 mg) for combination therapy with diclofinac potassium (10 mg) using Acetic acid induce writhing, Hot plate and Tail immersion methods. The test and standard drugs significantly (p<0.001) reduced the number of abdominal constriction and stretching of hind li...

The involvement of adenosinergic pathway in the anti-nociceptive effect of duloxetine, a balanced 5-HT/NE reuptake inhibitor, was evaluated in streptozotocin induced diabetic male albino mice of Laca strain. After four weeks of single injection of streptozotocin (200 mg/kg, ip), mice were tested in the tail immersion and hot-plate assays. Cerebral adenosine levels were measured by high-performa...

An absolute plate motion (APM) model is required to address issues such as the thermochemical evolution of Earth’s mantle. All APM models have to rely on indirect inferences, including those based on hot spots and seismic anisotropy, each with their own set of uncertainties. Here, we explore a seafloor spreading-aligned reference frame. We show that this reference frame fits azimuthal seismic a...

Our previously conducted pharmacological investigations led us to discovery of the strong local anesthetic activity of the compound KP-23RS. The following studies revealed that its Rand S-diasteroisomers had different activity in the local anesthetic, anti-aggregating, anti-arrhythmic and spasmolytic tests. Also the influence of KP-23RS and its diastereoisomers on the cyclic adenosine monophosp...

Buprenorphine HCl is a common analgesic for laboratory mice undergoing surgical procedures. The documented duration of action of buprenorphine HCl is as short as 3 to 5 h in mice, potentially necessitating readministration for continued analgesia. A long-acting buprenorphine formulation would reduce handling-associated stress and provide uninterrupted analgesia. This study used the hot-plate a...