Chrysoporthe austroafricana is a fungal pathogen that causes the development of stem cankers on susceptible Eucalyptus grandis trees. Clones of E. grandis that are partially resistant and highly susceptible have been identified based on the extent of lesion formation on the stem upon inoculation with C. austroafricana. These interactions have been used as a model pathosystem to enhance our unde...

MicroRNAs (miRNAs) have emerged as key players in host-pathogen interaction. Recently, many virus-encoded miRNAs have been identified from different mammalian species. However, the large family of invertebrate viruses of Baculoviridae, which infects diverse species of beneficial insects and agriculture pests, has hardly been investigated for elucidating the role of miRNAs in host-pathogen inter...

The stem rot disease has emerged globally as a major threat to oilseed Brassica's productivity and seed quality. generalist causal pathogen Sclerotinia sclerotiorum (Lib.) de Bary shows large variability in their aggressiveness pathogenicity. Revealing the pathogen's metabolic profile signaling components host-pathogen interaction is fundamental understanding host resistance disease. In this st...

Clustering protein-protein interaction (PPI) network data yields groups of proteins that are biochemically involved. Most existing clustering methods treat all the proteins in a PPI network equally. However, analyzing host-pathogen networks requires identification of clusters that represent the interactions between the set of pathogen proteins and the set of host proteins. For studying HIV-huma...

Globally, bacterial infections have been recognized as a predominant issue associated with significant morbidity and mortality. This global burden could be overcome by understanding the mechanism of both microbial virulence and host immune response. One approach to identify novel virulence strategies adopted by pathogens and host immune defense is to study the host-pathogen interaction using su...

Sepsis is one of the leading causes of mortality and morbidity in the world, and is an overreaction by the immune system due to pathogen invasion of the bloodstream. The interactions, particularly the protein interactions, between the host and pathogen are fundamental for the outcome of the disease. However, some of the protein interactions are unknown and those that are known have been studied...

A central challenge in host-pathogen systems biology is the elucidation of general, systems-level principles that distinguish host-pathogen interactions from within-host interactions. Current analyses of host-pathogen and within-host protein-protein interaction networks are largely limited by their resolution, treating proteins as nodes and interactions as edges. Here, we construct a domain-res...