OBJECTIVE Dysregulation of dopaminergic neurotransmission at the D1 receptor in the prefrontal cortex has been implicated in the pathogenesis of schizophrenia. Genetic polymorphisms of the dopamine D1-receptor gene have a plausible role in modulating the risk of schizophrenia. To determine the role of DRD1 genetic polymorphisms as a risk factor for schizophrenia, we undertook a case-control stu...

Reelin is an extracellular signaling protein that plays an important role in the development of the central nervous system. Post-mortem studies have shown lower reelin protein levels in the brains of patients with schizophrenia and bipolar disorder compared with controls. Genetic studies have also shown that mutations in the reelin gene (RELN) increase the risk for schizophrenia and bipolar dis...

BACKGROUND Schizophrenia is a major psychiatric disorder with a deeply destructive pathophysiology. There are evidences to indicate that infectious agents such as Toxoplasma gondii may play some roles in etiology of the disorder. OBJECTIVES The current study aimed to determine the association between T. gondii exposure and the risk of schizophrenia. MATERIALS AND METHODS T. gondii IgG antib...

objective: suicide is one of the most important early causes of death in psychotic patients. the main object of this research was to determine the relationship between positive and negative symptoms of schizophrenia and psychotic major depressive disorder (mdd) with suicidal history and risk. methods: sixty five patients with schizophrenia compared to 65 patients with psychotic mdd in a cross s...

Epidemiological and monozygotic twin studies indicate that the risk for developing schizophrenia is conferred equally by genetic and environmental factors. While the search for genes that increase susceptibility for schizophrenia has been a focus of recent researchefforts, similar efforts need tobemade to identify environmental risk factors, particularly those that are amenable to modification....

Cardiovascular morbidity and mortality are important problems among patients with schizophrenia. A wide spectrum of reasons, ranging from genes to the environment, are held responsible for causing the cardiovascular risk factors that may lead to shortening the life expectancy of patients with schizophrenia. Here, we have summarized the etiologic issues related with the cardiovascular risk facto...

BACKGROUND The aim of this review was to systematically review and meta-analyze the effects of yoga on symptoms of schizophrenia, quality of life, function, and hospitalization in patients with schizophrenia. METHODS MEDLINE/Pubmed, Scopus, the Cochrane Library, PsycInfo, and IndMED were screened through August 2012. Randomized controlled trials (RCTs) comparing yoga to usual care or non-phar...

OBJECTIVE Patients with schizophrenia enrolled in a trial of long-acting injectable risperidone at multiple sites of the Veterans Health Administration (VHA). We considered if the trial participants were representative of the targeted group of high-utilization patients with poor adherence to anti-psychotics. METHODS Participants' characteristics, health services utilization, and cost in the y...