The acute response of parathyroid hormone to perturbations in serum ionized calcium ([Ca(2+)]) is physiologically complex, and poorly understood. The literature provides numerous observations of quantitative and qualitative descriptions of parathyroid hormone (PTH) dynamics. We present a physiologically based mathematical model of PTH secretion constructed from mechanisms suggested in the liter...

AGROUP OF AFRICAN GREY parrots kept indoors on the premises of a parrot breeder in the UK are being studied longitudinally over 3 years to monitor the effects of staged changes in husbandry on calcium metabolism. The study group consists of 100 healthy adult African grey parrots of known sex that were fed a seed diet for 12 months prior to the beginning of the study. Fecal samples were taken fr...

Homeostasis of ionized calcium in biofluids is critical for human biological functions and organ systems. Measurement of ionized calcium for clinical applications is not easily accessible due to its strict procedures and dependence on pH. pH balance in body fluids greatly affects metabolic reactions and biological transport systems. Here, we demonstrate a wearable electrochemical device for con...

Since 2012, citrate anticoagulation is the recommended anticoagulation strategy for continuous renal replacement therapy (CRRT). The main drawback using citrate as anticoagulant compared with heparin is the need for calcium replacement and the rigorous control of calcium levels. This study investigated the possibility to achieve anticoagulation while eliminating the need for calcium replacement...

Introduction. The problem of secondary hyperparathyroidism (SHPT) and tertiary (THPT) has drawn the attention numerous researchers in many countries, including those where kidney transplantation is a routine procedure. most acute aspects include determining effective methods therapeutic treatment, diagnostic prognostic criteria, indications for surgery, its scope, avoiding relapses.
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In vitro calcium modulation of anterior pituitary hormone secretion has been well described. In addition, several investigations performed in human subjects have documented modulation of the circulating levels of pituitary hormones by supraphysiological calcium concentrations. Recent data from our laboratory document the existence of an extracellular calcium-sensing receptor that is thought to ...

OBJECTIVE To ascertain whether the parathyroid hormone (PTH) secretion of continuous ambulatory peritoneal dialysis (CAPD) uremic patients could be suppressed by repeated subcutaneous injections of calcitriol (CLT). DESIGN Nonrandomized prospective study with weekly evaluation. SETTING Hospital CAPD clinic. PATIENTS Seven uremic CAPD patients with signs of severe hyperparathyroidism. IN...