the majority of cancer treatments are invasive. gonadal injuries cause reductions in fertility which results in lack of hope for conception in cancer patients and frustration for their partners. fortunately, current advancements in cryopreservation and transplantation sciences regarding fertility preservation lead to cryostorage of gonads and preservation prior to the onset of chemo- and radiot...

Mating behavior in the male hamster is dependent upon both chemosensory and hormonal cues, and copulation is abolished if either signal is interrupted. Through reciprocal interactions of these signals, chemosensory stimuli increase circulating testosterone in the male, and the male's hormonal status influences his attraction to female pheromones. Furthermore, anatomical data suggest that these ...

BACKGROUND The effectiveness of postmastectomy radiation (PMRT) in breast cancer patients with N2 and N3 nodal status is often evaluated in combination with other postmastectomy adjuvant treatments. To account for interaction effects and determine the individual impact of PMRT alone, the National Cancer Data Base (NCDB) was analyzed from 2004-2011. PATIENTS AND METHODS We evaluated a cohort o...

We have generated DNA methylation profiles of 148 human breast tumors and found significant differences in hormone receptor (HR) status between clusters of DNA methylation profiles. Of 35 DNA methylation markers analyzed, the ESR1 gene, encoding estrogen receptor alpha, proved to be the best predictor of progesterone receptor status, whereas methylation of the PGR gene, encoding progesterone re...

We have generated DNA methylation profiles of 148 human breast tumors and found significant differences in hormone receptor (HR) status between clusters of DNA methylation profiles. Of 35 DNA methylation markers analyzed, the ESR1 gene, encoding estrogen receptor , proved to be the best predictor of progesterone receptor status, whereas methylation of the PGR gene, encoding progesterone recepto...

Breast cancer is the most common cancer in women worldwide, with nearly 1.7 million new cases diagnosed in 2012 (second most common cancer overall). This represents about 12% of all new cancer cases and 25% of all cancers in women [1]. Breast cancer is a leading cause of death in women [2]. Incidence of breast cancer is low in India compared to western countries, but it is associated with poor ...

It has been shown that women's preference for masculinity in male faces changes across the menstrual cycle. Preference for masculinity is stronger when conception probability is high than when it is low. These findings have been linked to cyclic fluctuations of hormone levels. The purpose of the present study is to further investigate the link between gonadal steroids (i.e. testosterone, estrad...

BACKGROUND Studies have reported current hormonal contraceptive use is associated with adverse cardiovascular outcomes, including high blood pressure. The aim of this study was to determine the association between past hormonal contraception use and high blood pressure in Australian postmenopausal women. METHODS Women were recruited from the 45 and Up Study, an observational cross-sectional s...

OBJECTIVES Since 2000, the Province of Quebec has experienced a shortage of physicians and a decrease in access to prescription contraceptives. A task-shifting strategy was launched in 2007 to allow trained nurses, in collaboration with community pharmacists, to start healthy women on hormonal contraception for a six-month period without a medical consultation. This study examined the proportio...

The aim of this study was to examine the pattern of attendance of patients requesting Emergency Hormonal Contraception (EHC) at an accident and emergency department before and after a government driven change in legislation, which allowed EHC to be sold over-the-counter by trained pharmacists, to women aged 16 years and above. We employed retrospective comparative study using computer records o...