OBJECTIVE Systemic oxidative stress causes insulin resistance in rodents. We tested the hypothesis that oxidative stress and insulin resistance are associated in humans. RESEARCH DESIGN AND METHODS We used cross-sectional data from 2,002 nondiabetic subjects of the community-based Framingham Offspring Study. We measured insulin resistance with the homeostasis model and defined categorical ins...

OBJECTIVE The extent to which abnormal glucose metabolism increases the risk of depression remains unclear. In this study, we investigated prospective associations of levels of fasting glucose and fasting insulin and indices of insulin resistance and secretion with subsequent new-onset depressive symptoms (DepS). RESEARCH DESIGN AND METHODS In this prospective cohort study of 3,145 adults fro...

Our study was aimed at the evaluation of relationships between thyroid stimulating hormone (TSH) within normal range and metabolic risk factors (glucose, insulin, HOMA-IR lipoprotein profile) in physically active male female students. In 219 students circulating TSH, glucose, insulin lipoproteins were measured blood under fasting conditions. Insulin resistance expressed as (homeostasis model as...

Background: To investigate the association between serum lipoprotein levels and insulin resistance in women with polycystic ovarian syndrome (PCOS). Methods: Twenty-five PCOS patients and twentyfive age-matched controls were enrolled in the study. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), fasting glucose (FBG), fasting insulin (FINS), serum triglycerides (TG)...

PPARs play a pivotal role in regulating lipid and glucose homeostasis and are involved in diverse biological activities in skin. Pomegranate flower (PGF, an antidiabetic therapy in Unani and Ayurvedic medicines) has been previously demonstrated to activate both PPARalpha/gamma. Here, we found that treatment of mice with the diet containing PGF powder over 55 weeks attenuated ageing-induced abno...

Objective: Forkhead box proteins and Forkhead box transcription factor O1 (FOXO1) in particular, mediate insulin signaling pathways and glucose homeostasis. This study aimed to compare FOXO1 expression in subcutaneous adipose (SA) tissue between obese rats with and without type 2 diabetes (T2D) and its response to resistance training in T2D. Materials and Methods: 21 male wistar rats (220±20 g...

Behaviours of several animal species have been linked to lunar periodicity. Evidence for such links in humans is weak; however, recently, shorter sleep duration was reported around full moon in two small samples of adults. As restrictions in sleep duration have been shown to adversely affect glucose regulation and physical activity to improve glucose regulation, one could speculate that cardiom...

BACKGROUND/AIMS Controversial results have been found in literature for the association between insulin resistance and sustained virologic response to standard chronic hepatitis C treatment. This study aims to provide a systematic literature review with meta-analysis, in order to evaluate if insulin resistance interferes with sustained virologic response in patients infected by the HCV genotype...