In this BMJ Confidential (BMJ 2014;349:g7093, doi:10.1136/ bmj.g7093) Kim Holt said that, if she could be invisible for 24 hours, she would like to attend the discussions at the Department of Health on the Francis review. In editing the piece, we mistakenly referred to this as being the Francis inquiry into the Mid Staffordshire Foundation Trust, which was chaired by Robert Francis and publishe...

In the Beverton Holt difference equation of population biology with intrinsic growth parameter above its critical value, any initial non-zero population will approach an asymptotically stable fixed point, the carrying capacity of the environment. When this carrying capacity is allowed to vary periodically it is known that there is a globally asymptotically stable periodic solution and the avera...

Holt-Oram syndrome is clinically characterized by morphological abnormalities of the upper limbs and congenital cardiac defects. Although the disease is congenital, the diagnosis may only be made later in life. It is a rare autosomal dominant disorder, caused by a mutation in the TBX5 gene located on chromosome 12, but sporadic cases have also been reported. We describe the case of a 75-year-ol...

Introduction Holt & Oram (1960) linked various skeletal abnormalities with congenital heart disease in four generations of a family. In particular, malformations of the hands were associated with atrial septal defect (secundum type) and bizarre arrhythmias. In 1961, McKusick described a similar syndrome in a mother and daughter and suggested the term 'atrio-digital dysplasia'. Harris & Osborne ...

Holt and Klee have recently shown that every (generic) LP orientation of the graph of a d-polytope satisfies a directed version of the d-connectivity property, i.e. there are d internally disjoint directed paths from a unique source to a unique sink. We introduce two new classes HK and HK* of oriented matroids (OMs) by enforcing this property and its dual interpretation in terms of line shellin...

A clinical and genetic study of the Holt-Oram syndrome (HOS) has been carried out in the United Kingdom involving 55 cases designated Holt-Oram syndrome, together with their parents and sibs. Data from the clinical assessment of both familial and isolated cases were used to define the HOS phenotype and to outline the spectrum of abnormalities, especially factors affecting severity. Skeletal def...

Holt-Oram syndrome is an autosomal dominant disorder, characterised by skeletal abnormalities of the upper limb associated with congenital heart defect, mainly atrial and ventricular septal defects. Skeletal defects exclusively affect the upper limbs in the preaxial radial ray distribution and are bilateral and asymmetrical. They range from clinodactyly, absent or digitalised thumb, hypoplastic...

ABSTRAK
 Indeks Harga Konsumen (IHK) dapat digunakan sebagai indikator ekonomi dan ukuran tingkat biaya produksi, serta berguna dalam memantau kenaikan harga pendapatan. Pemerintah perlu secara berkala menyesuaikan kebijakan inflasi IHK untuk menjaga stabilitas situasi rakyat, mengingat berubah setiap bulan. Penelitian ini bertujuan mengoptimalkan parameter melakukan peramalan periode Nove...