PURPOSE The hollow fiber assay is used successfully as a routine in vivo screening model to quantitatively define anticancer activity by the National Cancer Institute. This study investigates whether the hollow fiber assay can be used as a short-term in vivo model to demonstrate specific pharmacodynamic end points, namely microtubule and cell cycle disruption. EXPERIMENTAL DESIGN The growth o...

We demonstrate two-mode multiplexing at 2×10.7 Gbps over 7-cell hollow-core photonic band gap fiber. BER performances below FEC threshold limit (3.3×10 -3 ) are shown for both data channels. OCIS codes: (060.2270) Fiber characterization; (060.2330) Fiber optics communications

We present a fluid dynamics model for the drawing of hollow multilayer polymer optical fiber. A newtonian model is considered assuming slender geometries. Hollow core collapse during drawing and layer thickness non-uniformity are investigated as a function of draw temperature, draw ratio, feeding speed, core pressurization and mismatch of material properties in a multilayer.

Hollow fibre cell fishing with HPLC (HFCF-HPLC) based on the human ovarian cancer cell line SKOV-3, human renal tubular cell line ACHN or hepatoma cell line HepG-2 was employed to screen active groups of coumarin and volatile oil in Radix angelicae sinensis, Radix angelicae dahuricae and Fructus citri sarcodactylis. Simultaneously, hollow fibre liquid phase microextraction with HPLC (HFLPME-HPL...

Four-wave optical parametric amplification (FWOPA) in a Raman-active medium is experimentally investigated by use of an air-filled hollow fiber. A femtosecond pump pulse shorter than the period of molecular motion excites the coherent molecular motion of the Raman-active molecules during the parametric amplification of a signal pulse. The excited coherent motion modulates the frequency of the s...

The difficulty of fusion splicing hollow-core photonic bandgap fiber (PBGF) to conventional step index single mode fiber (SMF) has severely limited the implementation of PBGFs. To make PBGFs more functional we have developed a method for splicing a hollow-core PBGF to a SMF using a commercial arc splicer. A repeatable, robust, low-loss splice between the PBGF and SMF is demonstrated. By filling...

A technique for enhanced generation of selected high harmonics in a gas medium, in a high ionization limit, is proposed in this paper. An aperiodically corrugated hollow-core fiber is employed to modulate the intensity of the fundamental laser pulse along the direction of propagation, resulting in multiple quasi-phase-matched high harmonic emissions at the cutoff region. Simulated annealing (SA...

We present detailed instructions for constructing and operating an optical trap using a hollow core fiber and two-laser beams. The trap is stable, confining 100-nm to 10-mm particles of a variety of materials for hours of leisurely observation. The trap operates at room temperature and atmospheric pressure, costs less than $1400, and requires no machining. The hollow fiber provides automatic re...

A polypropylene hollow fiber membrane module is used for separating dissolved gases which contain dissolved oxygen from water. These dissolved gases can be used for underwater breathing. To be used for a human, the minimum amount of oxygen is essential. To increase separation of dissolved gases, much water and high surface area of hollow fibers are requested. For efficient separation system, pe...

We demonstrate a high sensitivity all­fiber Mach–Zehnder interferometer (MZI) based on radial­aligned liquid crystal (LC) in a hollow optical fiber (HOF). The transmission spectrum of the liquid crystal­filled fiber MZI (LCF­MZI) was measured at different temperatures, and the thermal­induced wavelength shift of the interference spectrum probed. The experimental results indicate that the LC ali...