نتایج جستجو برای: hma
تعداد نتایج: 711 فیلتر نتایج به سال:
BACKGROUND A sensitive gas chromatography-mass spectrometry method was developed and validated for the simultaneous measurement of MDEA, MDMA, and its metabolites, 3,4-methylenedioxy-N-ethylamphetamine (MDEA), 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy), and its metabolites, 4-hydroxy-3-methoxyamphetamine (HMA), 3,4-methylenedioxyamphetamine (MDA), and 4-hydroxy-3-methoxyamphetamine (HM...
In this study, we have investigated the diversity of current HIV-1 strains circulating in the metropolitan area of Lisbon, Portugal. A total of 217 HIV-1-positive blood samples, collected between October 1998 and December 2000, was genetically characterized in the gp120 C2V3C3 region (n = 205) or part of the gp41 N-terminal segment (n = 12) by heteroduplex mobility assay (HMA) and/or DNA sequen...
Specific phenotypic subpopulations of cancer stem cells (CSCs) are responsible for tumor development, production of heterogeneous differentiated tumor mass, metastasis, and resistance to therapies. The development of therapeutic approaches based on targeting rare CSCs has been limited partially due to the lack of appropriate experimental models and measurement approaches. The current study pres...
Human tissue-specific genome-scale metabolic models (GEMs) provide comprehensive understanding of human metabolism, which is of great value to the biomedical research community. To make this kind of data easily accessible to the public, we have designed and deployed the human metabolic atlas (HMA) website (http://www.metabolicatlas.org). This online resource provides comprehensive information a...
Hot mixed asphalt (HMA) is a mixture of particles (coarse and fine aggregates) interstitial fluid (asphalt binder) designed to compact harden for long-lasting roads. In this study, we implement two-scale approach capture the compaction behaviour hot mixtures using both granular-slurry rheology (GSR) at smaller scale discrete element method (DEM) simulation compactor. We show that modelling effo...
Abstract High Mountain Asia (HMA) glaciers are critical water reserves for montane regions, which readily influenced by climate change. The glacier mass balance during 2000–2021 over HMA was estimated comparing the elevations from ICESat-2 and NASADEM. Radar penetration depth could be one of intrinsic error sources in estimating using Therefore, we doubled elevation differences between X-band S...
Several vasoconstrictor agents can regulate the phosphorylation status of the Na(+)-K(+) ATPase (NKA). We have recently demonstrated that mammalian tissues contain an endogenous bufadienolide, digitalis-like alpha(1)-NKA-selective ligand, marinobufagenin (MBG). Protein kinase C induces phosphorylation of the alpha(1)-NKA isoform, the major isoform in vascular smooth muscle, kidney, and heart ce...
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