Gene variants derived from Neanderthals or Denisovans can be associated with polygenic traits, validating the utility of notion about archaic gene flow. Endoplasmic reticulum aminopeptidase 1 (ERAP1) haplotypes control disease risk primarily mediated by HLA-C*06:02, HLA-B*27 and HLA-B*51 for psoriasis, ankylosing spondylitis (AS) Behçet's (BD). In this genetic interaction corresponds to differe...

Abstract Sensitization to nickel (Ni2+) is the most common T cell mediated type IV hypersensitivity, although mechanisms by which Ni2+ alters antigen presentation are not understood. To study how TCR then recognizes bound MHC molecule, we performed paired single RNA sequencing of PBMCs from two highly sensitized subjects orthopedic implants and characterized three specific CD4+ clones. One rest...

Background: HLA compatibility between transplant donor and recipient is one of the major determinants of transplant outcome. Objective: To determine HLA class I by PCR- Sequence-Specific Oligonucleotide Probe (PCR-SSOP) in cord blood donors. Methods: Genomic DNA of 142 cord blood samples registered at the Cord Blood Bank of Iran at Hematology, Oncology, and Bone Marrow Transplantation Researc...

Psoriasis (PsO) is a T cell-mediated autoimmune disease without cure. The major risk-associated PsO susceptibility gene encodes for the human leukocyte antigen C*06:02 (HLA-Cw6). Half of patients carry this allele encoding HLA-I molecule which presents short peptides (together known as immunopeptidome) to CD8 cells, thereby initiating immune responses. It unclear presented by HLA-Cw6 are preval...

Progression of oral squamous cell carcinoma (OSCC) has been associated with an escape tumor cells from the host immune surveillance due to increased knowledge its underlying molecular mechanisms and modulation by microenvironment repertoire. In this study, expression HLA class I (HLA-I) antigens components antigen processing machinery (APM) was analyzed in 160 pathologically classified human pa...

The human leukocyte antigen G (HLA-G) molecule exhibits limited tissue distribution, low polymorphism and alternative splicings that generate seven HLA-G isoforms. HLA-G exerts multiple immunoregulatory functions. Recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from anti-tumor immune responses. This study it is an effort to clarify the presence of HLA...

Background Alzheimer’s disease (AD), Parkinson’s (PD), Amyotrophic Lateral Sclerosis (ALS) and other neurodegenerative diseases are responsible for considerable morbidity mortality. With incidence rising with aging, these also represent a growing societal challenge. Pathophysiology involves accumulation of tau (neurofibrillary tangles) Amyloid-β-rich (amyloid plaques) aggregates in AD, α-synucl...

Abstract. This article presents a Data Quality Assurance (DQA) tool for 3D city buildings, which is developed using the FME Workbench application. It evaluates quality of both CityGML and CityJSON data sets against predefined rules produces information in tabular or geometrical format. All violations are categorized based on their severity, means that can automatically discard fix some found er...