نتایج جستجو برای: hla class i

تعداد نتایج: 1404625  

Journal: :iranian journal of allergy, asthma and immunology 0
fathemeh yari ahmad zavaran hosseini mohsen nemat gorgani mohammad reza khorramizadeh parvin mansouri anoshirvan kazemnejad

studies on hla-g, a nonpolymorphic antigen of non-classical hla class i, is of basic and clinical significance. in the present study, the expression of hla-g proteins in the human skin tissue sections of normal and autoimmune pemphigus vulgaris (pv) individuals were investigated using monoclonal antibodies. the antibodies recognized both membrane-bound and soluble isoforms of hla-g. rt-pcr was ...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Marco Vitale Giuseppe Pelusi Beatrice Taroni Giuliana Gobbi Cristina Micheloni Rita Rezzani Francesco Donato Xinhui Wang Soldano Ferrone

PURPOSE To investigate TAP1, TAP2, and HLA class I antigen expression in primary ovarian carcinoma lesions and to assess the clinical significance of defects in the expression of these molecules. EXPERIMENTAL DESIGN Fifty-one formalin-fixed, paraffin-embedded primary ovarian carcinoma lesions were stained with affinity-purified rabbit anti-TAP1 and anti-TAP2 antibodies and with anti-HLA class...

2002
Bela Chauhan Patricia S. Hutcheson Raymond G. Slavin Clifford J. Bellone

1. Abstract 2. Introduction 3. MHC Class I and II Molecules 3.1. Function of MHC Class I and Class II molecules 3.2. Structure of MHC Class I and Class II molecules 3.3. Antigen binding by MHC Class I and Class II molecules 3.4. MHC polymorphism on peptide binding 3.5. Antigen presentation by MHC Class II molecules 4. MHC and disease associations 4.1. Associations between MHC polymorphism and d...

Journal: :The Journal of Infectious Diseases 2003

2008

Description The genes of the Human Leukocyte Antigen (HLA) system reside on chromosome 6, and code for cellsurface proteins that play a crucial role in the presentation of endogenic peptides to effector cells of the immune system. The HLA Class I protein molecule is a heterodimer, made up of two chains; a heavy one and a light one (beta 2 microglobulin). The HLA-B gene is one of the three HLA C...

Journal: :Cancers 2021

Progression of oral squamous cell carcinoma (OSCC) has been associated with an escape tumor cells from the host immune surveillance due to increased knowledge its underlying molecular mechanisms and modulation by microenvironment repertoire. In this study, expression HLA class I (HLA-I) antigens components antigen processing machinery (APM) was analyzed in 160 pathologically classified human pa...

2015
Ingrid M. Schellens Hugo D. Meiring Ilka Hoof Sanne N. Spijkers Martien C. M. Poelen Jacqueline A. M. van Gaans-van den Brink Ana I. Costa Harry Vennema Can Keşmir Debbie van Baarle Cécile A. C. M. van Els

Immunity to infections with measles virus (MV) can involve vigorous human leukocyte antigen (HLA) class I-restricted CD8(+) cytotoxic T cell (CTL) responses. MV, albeit regarded monotypic, is known to undergo molecular evolution across its RNA genome. To address which regions of the MV proteome are eligible for recognition by CD8(+) CTLs and how different HLA class I loci contribute to the epit...

Journal: :Journal of immunology 2002
Eve Cheuk Celine D'Souza Ningjie Hu Youan Liu Haili Lang John W Chamberlain

Although mice transgenic (Tg) for human MHC (HLA) class I alleles could provide an important model for characterizing HLA-restricted viral and tumor Ag CTL epitopes, the extent to which Tg mouse T cells become HLA restricted in the presence of endogenous H2 class I and recognize the same peptides as in HLA allele-matched humans is not clear. We previously described Tg mice carrying the HLA-B27,...

Journal: :Journal of immunology 1999
S Martinozzi R Pacasova H J Boulouis M Ulbrecht E H Weiss F Sigaux M Pla

The human nonclassical MHC class I molecule HLA-E has recently been shown to act as a major ligand for NK cell inhibitory receptors. Using HLA-E-expressing transgenic mice, we produced a cytotoxic T cell clone that specifically recognizes the HLA-E molecule. We report here that this T cell clone lyses HLA-E-transfected RMA-S target cells sensitized with synthetic class I signal sequence nonamer...

2006
Toshiro Kageshita Zhigang Wang Lido Calorini Akira Yoshii Toru Kimura Tomomichi Ono Sebastiano Gattoni-Celli Soldano Ferrone

Immunoperoxidase staining of frozen sections from surgically removed melanoma lesions showed that anti-human leukocyte antigen (HLA)-A2, A28 monoclonal antibody (mAb) stained keratinocytes, but did not stain melanoma cells in 21% of the 14 primary and 44% of the 9 metastatic lesions tested. The loss of HLA-A2 and/or A28 allospecificities did not affect the staining patterns with mAb recognizing...

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