Objective To explore genetic association between human leukocyte antigen (HLA) and neurodegenerative diseases investigate mechanisms behind the association. Background Pathophysiology of Alzheimer's disease (AD), Parkinson's (PD) amyotrophic lateral sclerosis (ALS) involves accumulation tau (neurofibrillary tangles) amyloid-ß-rich (amyloid plaques) aggregates in AD, a-synuclein-rich (Lewy bodie...

Đặt vấn đề: Gen HLA (kháng nguyên bạch cầu người) nằm trên nhánh ngắn nhiễm sắc thể số 6, được chia thành 3 lớp với các locus gen khác nhau. Việc xác định kiểu là rất cần thiết trong ghép, đặc biệt ghép tế bào gốc tạo máu. Đối tượng và phương pháp: Nghiên cứu cắt ngang tỷ lệ allele HLA-A, HLA-B, HLA-C HLA-DRB1 138 người cho máu tại Bệnh viện Nhi Trung ương từ năm 2010 - 2020. Kiểu bằng pháp PCR...

Objectives: Despite the improvements in early-term outcomes of kidney transplantation, late-term graft failure still remained as a critical problem. De novo donor specific antibodies (DSA) developing against direct human leukocyte antigens (HLA) are significant risk factors for shortened survival previously non-sensitized cases. The purpose this study is to evaluate clinical de DSA development ...

Introduction Several lines of evidence support the contribution of autoimmune mechanisms in the pathogenesis of Meniere’s disease. The aim of this study was determining the association between HLA-Cw Alleles in patients with definite Meniere’s disease and patients with probable Meniere’s disease and a control group.  Materials and Methods: HLA-Cw genotyping was performed in 23 patients with def...

the  non-classical mhc  class-i mainly involves in the  regulation of  innate  immune responses where hla-e  plays a significant role in the cell identification by natural killer cells. hla-e is a main regulatory ligand for natural killer cells and given the importance of these effector cells in hematopoietic stem cell transplantation, we investigated the effect of hla-e polymorphisms on post-h...

HLA-B*13:01 is associated with dapsone (DDS)-induced hypersensitivity and it has been shown that CD4+ CD8+ T cells are activated by DDS its nitroso metabolite (DDS-NO). However, there a need to define the importance of HLA association in disease pathogenesis. Thus, DDS-NO-specific cell clones (TCC) were generated from hypersensitive patients expressing assessed for phenotype function, HLA-allel...

Abstract Major histocompatibility (MHC) bound viral peptides are the immune signatures to initiate selective and cross-reactive T cell responses. Identifying antigenic targets of adaptive immunity SARS-CoV-2 is a key towards understanding pathogenesis Sars-CoV-2 rapidly evolving mutants. We isolated immunopeptidomes identify naturally processed presented MHC-II (HLA-DR, HLA-DP) MHC-I (HLA-ABC) ...

The present investigation was focussed to evaluate the mechanical properties of AA7075 subjected corrosion and heat treatment. Exfoliation has been used infuse rapid on material coupled with high temperature subsequent low-temperature aging (HLA). It found that localized pit formation occurs HLA exposure durations substantial inter-granular changes cracks. Significant reduction in observed HLA-...

Major histocompatibility complex (MHC) is consisted of cluster genes known as human leukocyte antigen HLA, these are committed to process and present antigens T lymphocyte. Corona viruses, belonging a genus the corona viridae family, enveloped viruses containing single stranded RNA 27-32 kb. This study was conducted highlight some observations that may help other researcher for rapid research a...

introduction: human leukocyte antigen (hla) genes are the most polymorphic loci in the human genome. they predict the outcome of transplantation by detecting self from non-self antigens. the best use of hla typing is to find a hla-match donor for bmt candidate patients. evidence suggests that matching unrelated donors and recipients for hla-a, -b and -drb1 loci is a prediction for an improved o...