Effective treatments for cancer are still needed, both for cancers that do not respond well to current therapeutics and for cancers that become resistant to available treatments. Herein we investigated the effect of a structure-selective d-amino acid peptide wrwycr that binds replication fork mimics and Holliday Junction (HJs) intermediates of homologous recombination (HR) in vitro, and inhibit...

The faithful duplication of an entire genome is a complex affair requiring the coordinated action of the DNA replisome to unwind and synthesize DNA at replication forks. Unfortunately, exposure to chemicals or radiation can damage DNA strands, and this damage can stall DNA replication forks, resulting in genome instability, tumorigenesis, or cell death. To rescue stalled replication forks, cell...

Autonomous coverage of a specified area by robots operating in close proximity with each other has many potential applications such as real-time monitoring rapidly changing environments, and search rescue; however, coordination safety are two fundamental challenges. For coordination, we propose distributed controller for covering moving, compact domains which consists double integrator bounded ...

Flood forecasting and management are one of the most important strategies necessary for water resource decision planners in combating flood problems. The Muskingum model is popular widely used applications purpose predicting routing. particle swarm optimization (PSO) methodology was to estimate coefficients nonlinear this study, comparing results with methods genetic algorithm (GA), harmony sea...

effect of infarct age and residual regional myocardial blood flow. Circulation 60: 297-303, 1979 8. Davies RA, Thakur ML, Berger HJ, Wackers FJ, Gottschalk A, Zaret BL: Imaging the inflammatory response to acute myocardial infarction in man using Indium-111 labelled autologous leucocytes. Circulation 63: 826-832, 1981 9. Yates PO: Vascular disease of the central nervous system (chap. 3). In Bla...

The RecG helicase of Escherichia coli unwinds both Holliday junction (HJ) and replication fork DNA substrates. Our lab previously identified and characterized peptides (WRWYCR and KWWCRW) that block the activity of RecG on these substrates. We determined that the peptides bind HJ DNA and prevent the binding of RecG. Herein, we present further evidence that the peptides are competitive inhibitor...

summary. The aim of this investigation was to identity effective criteria for classification of salt tolerance and salt sensitivity in rice cultivars by using multivariate characters. Osmolarity in salt-stressed leaves decreased, and was positively related to low water potential (Ψ w) (r 2 =0.99 and r 2 =1), leading to chlorophyll a degradation (r 2 =0.65 and r 2 =0.77) in both salt-tolerant (H...

The aim of this study was to profile physical characteristics of soccer players measured by acceleration, vertical jump (VJ), horizontal jump (HJ) and change of direction ability (CODA) tests, and to quantify the relationships between these characteristics. Additionally, leg asymmetries between the dominant and nondominant legs during unilateral VJ and HJ were assessed. Thirty-nine male soccer ...

Provably safe and scalable multi-vehicle path planning is an important and urgent problem due to the expected increase of automation in civilian airspace in the near future. Although this problem has been studied in the past, there has not been a method that guarantees both goal satisfaction and safety for vehicles with general nonlinear dynamics while taking into account disturbances and poten...

Roux-en-Y (RY) hepaticojejunostomy (HJ) is a critical component of complex hepatobiliary operations, and it is the treatment of choice for post-cholecystectomy biliary strictures (PCBS). Complications related to the Roux limb, particularly those leading to cholangitis, can severely compromise outcomes. We present a case of a 54-year-old lady who had previously undergone two HJ procedures for re...