A fractional order mathematical model that already exists in the literature, was considered. This established to study effects of medicinal treatment people infected with human immunodeficiency virus (HIV). The importance this is evaluates, among other parameters, density healthy and HIV-infected CD4+ T cells. These data are very necessary for subject by given an antiretroviral causes it. objec...

Narrative Justification: NIDA supports a broad range of research on the drug abuse aspects of HIV/AIDS in diverse, drug using populations to reduce the acquisition and transmission of HIV associated with sharing injection paraphernalia and/or high risk sexual behavior, to improve HIV treatment including access and utilization of services, and to reduce the consequences of HIV/AIDS. Research on ...

BACKGROUND Injecting drug use is an increasingly important cause of HIV transmission in most countries worldwide, especially in eastern Europe, South America, and east and southeast Asia. Among people actively injecting drugs, provision of clean needles and opioid substitution reduce HIV-transmission. However, former injecting drug users (fIDUs) are often overlooked as a high risk group for HIV...

Drug resistance remains to be a serious problem with type I human immunodeficiency virus (HIV-1) non-nucleoside reverse transcriptase inhibitors (NNRTIs). A series of novel boronic acid-containing diarylpyrimidine (DAPY) derivatives were designed via bioisosterism and scaffold-hopping strategies, taking advantage the ability acid group form multiple hydrogen bonds. The target compounds synthesi...

Despite the wide variety of highly potent anti-HIV drugs that have been developed and made available in clinical practice over the years, eradication of HIV infection has not been achieved. Currently, HIV infection and AIDS are thought to be chronically treatable. HIV attacks host immune cells namely macrophages and CD4(+)T-cells and sequesters itself into sanctuary and reservoir sites such as ...

Raltegravir is the first approved human immunodeficiency virus type 1 (HIV-1) integrase inhibitor; it targets the strand transfer step of HIV-1 integration. Clinical trials have demonstrated that raltegravir-containing regimens have potent antiretroviral activity and are well tolerated in HIV-1-infected individuals. In antiretroviral treatment-experienced persons with drug-resistant HIV infecti...

background: acquired immune deficiency syndrome (aids) was firstly reported from california and soon became a pandemic in the world.this disease poses seriousthreats to humans’ health.in this study, we intended to examine the characteristicsof hiv-positive patients whoreferred to the behavioral diseases consultation center (bdcc) in shiraz, iran.   methods : this was a cross-sectional descripti...

background: hiv/aids control are one of the most important goals of the health systems. the aim of this study was to determine how hiv/aids control was initiated among policy makers' agenda setting in iran.   methods: a qualitative research (semi-structured interview) was conducted using kingdon's framework (problem, policy and politics streams, and policy windows and policy entrepreneurs) to a...