نتایج جستجو برای: histamine release and degranulation

تعداد نتایج: 16855534  

Journal: :Journal of immunology 2008
Ekaterina Shumilina Rebecca S Lam Florian Wölbing Nicole Matzner Irina M Zemtsova Malgorzata Sobiesiak Hasan Mahmud Ulrike Sausbier Tilo Biedermann Peter Ruth Matthias Sausbier Florian Lang

Mast cell stimulation by Ag is followed by the opening of Ca(2+)-activated K(+) channels, which participate in the orchestration of mast cell degranulation. The present study has been performed to explore the involvement of the Ca(2+)-activated K(+) channel K(Ca)3.1 in mast cell function. To this end mast cells have been isolated and cultured from the bone marrow (bone marrow-derived mast cells...

Journal: :The Practitioner 2011
Edward Holloway Adam Fox Roisin Fitzsimons

The prevalence of food allergy in children in the UK is now around 5%. The number of children put on restricted diets by their parents because of presumed allergy is likely to be much higher. Accurate diagnosis of food allergy is essential in order to ensure that the correct foods are carefully avoided while safe foods are not excluded unnecessarily. IgE-mediated (immediate type) reactions are ...

Journal: :The Journal of pharmacology and experimental therapeutics 2003
Claudia L Hofstra Pragnya J Desai Robin L Thurmond Wai-Ping Fung-Leung

The diverse physiological functions of histamine are mediated through distinct histamine receptors. Mast cells are major producers of histamine, yet effects of histamine on mast cells are currently unclear. The present study shows that histamine induces chemotaxis of mouse mast cells, without affecting mast cell degranulation. Mast cell chemotaxis toward histamine could be blocked by the dual H...

Journal: :British Journal of Anaesthesia 1986

2011
Dimitris N Xanthos Simon Gaderer Ruth Drdla Erin Nuro Anastasia Abramova Wilfried Ellmeier Jürgen Sandkühler

BACKGROUND Functional aspects of mast cell-neuronal interactions remain poorly understood. Mast cell activation and degranulation can result in the release of powerful pro-inflammatory mediators such as histamine and cytokines. Cerebral dural mast cells have been proposed to modulate meningeal nociceptor activity and be involved in migraine pathophysiology. Little is known about the functional ...

2012
M Komai-Koma F Brombacher P N Pushparaj B Arendse C McSharry J Alexander R Chaudhuri N C Thomson A N J McKenzie I McInnes F Y Liew D Xu

BACKGROUND The regulation and function of IgE in healthy individuals and in antigen-naïve animals is not well understood. IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation. METHODS IL-33 was administered to naïve wild-type (WT), nude and ST2(-/-) ,...

Journal: :The Journal of Cell Biology 1984
A M Dvorak I Hammel E S Schulman S P Peters D W MacGlashan R P Schleimer H H Newball K Pyne H F Dvorak L M Lichtenstein

We used a morphometric and autoradiographic approach to analyze changes in specific cytoplasmic granules and cytoplasmic lipid bodies associated with human lung mast cell degranulation. Mast cells were dissociated from lung tissue by enzymatic digestion and were then enriched to purities of up to 99% by countercurrent centrifugation elutriation and recovery from columns containing specific anti...

Journal: :Investigative ophthalmology & visual science 1986
D F Woodward S E Ledgard A L Nieves

The recent development of a technique for quantitative measurement of conjunctival microvascular permeability has permitted detailed pharmacological evaluation of H1- and H2-receptor involvement in histamine-induced increases in conjunctival microvascular permeability and the role of histamine in microvascular permeability changes associated with immediate hypersensitivity responses in the conj...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه صنعتی اصفهان - دانشکده منابع طبیعی 1392

nowadays, air pollution is a global problem that has had significant growth by technology development, population growth andindustrial development. industrial development brought natural resources deterioration, more manufacturing products, and more environmental pollutants. if pollutant won’t be controlled, human-being and wildlife will face the critical risks. significant release and critical...

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