PURPOSE To evaluate the variation in macular retinal thickness and volume in young Chinese myopic patients using time-domain optical coherence tomography (Stratus TD-OCT) and spectral-domain optical coherence tomography (Cirrus HD-OCT). METHODS Ninety-two eyes of 92 myopic subjects were recruited in this study. Based upon spherical equivalence (SE), subjects were divided into two groups: the ...

Purpose To quantify macular vascular density using optical coherence tomography angiography (OCTA) and to investigate its relationship with retinal thickness in myopic eyes of young adults. Methods In this cross-sectional study, 268 myopic eyes without pathological changes were recruited and divided into three groups: mild myopia (n = 81), moderate myopia (n = 117), and high myopia (n = 70). ...

OBJECTIVE Myopia is emerging as a public health problem in school going children. Prevalence of myopia differs in different geographical areas, race, ethnic groups and socioeconomic background. Purpose of this study was to find out myopia prevalence in schoolchildren from very high mountain region of Nepal. MATERIALS AND METHODS It was a cross sectional descriptive study. Vision screening was...

PURPOSE. This study examined the relationship between high myopia and three myopia candidate genes, namely matrix metalloproteinase 2 (MMP2) and tissue inhibitor of metalloproteinase 2 and 3 (TIMP2 and TIMP3), involved in scleral remodeling. METHODS. The study recruited unrelated adult Han Chinese who were high myopes (spherical equivalent ≤-6.0D for both eyes; cases) and emmetropes (within ±1....

Purpose. To investigate the correlation between aqueous and serum levels of pigment epithelium-derived factor (PEDF) and macular choroidal thickness in high myopia patients, both with and without choroidal neovascularization (CNV). Methods. Serum and aqueous levels of PEDF were measured by enzyme-linked immunosorbent assay in 36 high myopia patients (36 eyes) with no CNV (non-CNV group), 14 hig...

IMPORTANCE Analysis of retinal nerve fiber layer (RNFL) abnormalities with optical coherence tomography in eyes with high myopia has been complicated by high rates of false-positive errors. An understanding of whether the application of a myopic normative database can improve the specificity for detection of RNFL abnormalities in eyes with high myopia is relevant. OBJECTIVE To evaluate the di...

Background: High myopia (defined as of -6D or more) is one the main causes visual impairment worldwide. always accompanied by pathological structural changes such axial elongation, posterior staphyloma, lacquer crack formation, thinning retina and choroid, choroidal neovascularization.
 Aims Objectives: The purpose this study was to examine fundus in eyes with high myopia.
 Materials ...

BACKGROUND Myopia is a condition in which the focusing power (refraction) of the eye is greater than that required for clear distance vision. There are two main types of surgical correction for moderate to high myopia; excimer laser and phakic intraocular lenses (IOLs). Excimer laser refractive surgery for myopia works by removing corneal stroma to lessen the refractive power of the cornea and ...

OBJECTIVE To evaluate the association of insulin-like growth factor 1 gene rs12423791 and rs6214 polymorphisms with high myopia. METHODS An electronic search was conducted on PubMed, Embase, the Cochrane Library and the Chinese Biological Abstract Database for articles published prior to May 6, 2014. A meta-analysis was performed using Revman 5.1 and Stata 12.0, and the odds ratios with 95% c...

We report a case of 43 years old women who present myopic CNV (A) causing an acute vision loss. That has not been treated at time causing a chorioretinal atrophy as the angiography (B) and her Optical Coherence Tomography (OCT) (C) shows. High myopia is a major cause of legal blindness in many countries, especially in young people. Itis defined as a refraction of at least -6.00 diopters and/or ...