Trypanosoma cruzi is the causative agent of Chagas disease. Approximately 8 million people are thought to be affected worldwide. Several players in host lipid metabolism have been implicated in T. cruzi-host interactions in recent research, including macrophages, adipocytes, low density lipoprotein (LDL), low density lipoprotein receptor (LDLR), and high density lipoprotein (HDL). All of these ...

Background and aimsHeterogeneous high-density lipoprotein (HDL) particles, which can contain hundreds of proteins, affect human health disease through dynamic molecular interactions with cell surface proteins. How HDL mediates its long-range signaling functions various types is largely unknown. Due to the complexity HDL, we hypothesize that multiple receptors engage particles resulting in condi...

Cardiovascular diseases with an incidence of approximately 50% are the main causes of death in most advanced countries and an increasing trend in the developing world as well. The World Health Organization estimates that 12 million people per year worldwide die from cardiovascular diseases. Cardiovascular diseases are becoming an increasing problem worldwide and hypercholesterolemia has been co...