Twenty strains of Venezuelan encephalitis (VE) virus inoculated intravenously in large doses into roosters produced hemagglutination-inhibition (HI) antibodies detectable in plasmas within 7 to 10 days. No signs of illness occurred, and there was no evidence of viral growth in tissues since blood concentrations of infectious virus steadily decreased after inoculation. HI antibodies in early pla...

BACKGROUND Respiratory tract infections (RTIs) are amongst the most wide spread and serious infections, accounting for over 50 million deaths globally each year. In developing countries, infants under 4 years of age are at greatest risk of lower RTIs, whereas in developed countries the severity of infection and rate of mortality are greater in elderly. The objective of the survey was to determi...

Vocoder simulations are generally adopted to simulate the electrical hearing induced by the cochlear implant (CI). Our research group is developing a new four-electrode CI microsystem which induces high-frequency electrical hearing while preserving low-frequency acoustic hearing. To simulate the functionality of this CI, a previously developed hearing-impaired (HI) hearing model is combined wit...

The aim of this study was to investigate the prevalence of CIV H3N8 in dogs in Germany. Blood samples from 272 clinically healthy dogs and 35 dogs with acute respiratory signs were screened for antibodies against influenza virus by ELISA and haemagglutination inhibition (HI) assay; positive samples were further tested by fluorescent antibody test (FAT) and subtype-specific HI assay. Nasal and p...

BACKGROUND Intratumoural heterogeneity has been demonstrated to be a strong indicator of malignant transformation. Our study was to investigate pretreatment (18)F-FDG parameters, including (18)F-FDG based heterogeneity for predicting survival in patients with locally advanced nasopharyngeal carcinoma (NPC). METHODS Forty newly diagnosed, biopsy-proven locally advanced NPC patients who underwe...

OBJECTIVE The perception of pitch has recently gained attention. At present, clinical audiologic tests to assess this are hardly available. This article reports on the development of a clinical test using harmonic intonation (HI) and disharmonic intonation (DI). STUDY DESIGN Prospective collection of normative data and pilot study in hearing-impaired subjects. SETTING Tertiary referral cent...

We have completed a 21-cm survey of a 600 square degree region of the Centaurus A group of galaxies at a redshift of ∼500 km s−1 as part of a larger survey of the entire southern sky. This group of galaxies was recently the subject of a separate and thorough optical survey (Côté et al. 1997), and thus presented an ideal comparison for us to test the survey performance. We have identified 10 new...

BACKGROUND High-intensity noninvasive ventilation (HI-NIV) is the most effective means of improving several physiological and clinical parameters in subjects with chronic hypercapnic COPD. Whether the newer hybrid mode using target tidal volume noninvasive ventilation (target V(T) NIV) provides additional benefits remains unclear. METHODS Subjects with COPD successfully established on long-te...

One approach to treatment of negative cognitive effects associated with Alzheimer's disease and schizophrenia may involve activation of neuronal α7 nicotinic acetylcholine receptors (nAChRs). We used the α7-selective partial agonist 3-(4-hydroxy, 2-methoxy-benzylidene)anabaseine (4OHGTS-21), the α7 modulator 5-hydroxyindole (5-HI), and recombinant adeno-associated virus (rAAV)–mediated α7 gene ...