Hereditary hemochromatosis is caused by a potentially lethal recessive gene (HFE, C282Y allele) that increases iron absorption and reaches polymorphic levels in northern European populations. Because persons carrying the allele absorb iron more readily than do noncarriers, it has often been suggested that HFE is an adaptation to anemia. We hypothesize positive selection for HFE began during or ...

BACKGROUND AND OBJECTIVES In Italy, typical HFE mutations account for only 64% of the cases with overt hereditary hemochromatosis (HH), and a common HFE-unrelated disease was hypothesized. DESIGN AND METHODS One thousand and fifty potential blood donors were screened by iron tests, C282Y and H63D HFE mutation analysis in a region in North Italy. Subjects with repeated fasting transferrin satu...

Sicker patients with greater care needs are being discharged to their homes to assume responsibility for their own care with fewer nurses available to aid them. This situation brings with it a host of human factors and ergonomic (HFE) concerns, both for the home care nurse and the home dwelling patient, that can affect quality of care and patient safety. Many of these concerns are related to th...

Multivariate Public Key Cryptography (MPKC) has been put forth as a possible post-quantum family of cryptographic schemes. These schemes lack provable security in the reduction theoretic sense, and so their security against yet undiscovered attacks remains uncertain. The effectiveness of differential attacks on various field-based systems has prompted the investigation of differential propertie...

Multivariate Cryptography has been an active line of research for almost twenty years. While most multivariate cryptosystems have been under attack, variations of the basic schemes came up as potential repairs. In this paper, we study the Internal Perturbation variation of HFE recently proposed by Ding and Schmidt. Although several results indicate that HFE is vulnerable against algebraic attac...

PURPOSE Mutations of the HFE gene that cause hereditary hemochromatosis may be associated with an increased risk of cardiovascular disease. We examined the relation between two HFE mutations (C282Y and H63D), indicators of iron homeostasis, and the prevalence of coronary heart disease in a large population of white adults. SUBJECTS AND METHODS We conducted a cross-sectional study of 30,916 wh...

BACKGROUND Screening for hereditary hemochromatosis is traditionally done by using serum iron studies. However, mutation analysis of the hemochromatosis-associated HFE gene has recently become available. OBJECTIVE To compare the cost-effectiveness of no screening with four screening strategies that incorporate HFE gene testing or serum iron studies. DESIGN Cost-effectiveness analysis. DAT...