Humanity is facing a vast prevalence of neurodegenerative diseases, with Alzheimer’s disease (AD) being the most dominant, without efficacious drugs, and only few therapeutic targets identified. In this scenario, we aim to find molecular entities that modulate imidazoline I2 receptors (I2-IRs) have been pointed out as relevant in AD. work, explored structural modifications well-established I2-I...

In the title compound, C(16)H(17)FN(2)O(4)·H(2)O, the dihedral angle between the heterocyclic ring and the benzene ring is 5.77 (9)°, that between the heterocycle and the ethoxy-carbonyl plane is 15.5 (1)°, and that between the heterocyclic ring and the cyclopropane ring is 67.75 (13)°. In the crystal structure, mol-ecules are linked into a ribbon-like structure along the c axis by N-H⋯O and O-...

Herein, we report the synthesis of 12 new naphthoquinone derivatives, 6 substituted 1,4-naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their trypanocidal and leishmanicidal activities. Compounds 11a and 13a were active against the amastigote stage of T. cruzi and showed low cytotoxic effects. With respect to leishmanicidal assays, all compounds were inactive a...

In the title compound, [PbBr(2)(C(14)H(12)N(2))](n), the Pb(II) atom lies on a twofold rotation axis. The N-heterocycle-chelated Pb(II) atom exists in a distorted octa-hedral geometry owing to two long Pb⋯Br inter-actions [2.9562 (5) and 3.2594 (5) Å]. These result in a zigzag chain running along the c axis. The lone pair is stereochemically inactive.

In the title compound, C(18)H(21)BrN(2)O(5), conjugation between the π-donating N-C-O fragment and the π-withdrawing carbonyl group results in considerable redistribution of the electron density within the dihydropyridinol ring. This effect is also promoted by the formation of an intra-molecular N-H⋯O hydrogen bond. The five-membered heterocycle is disordered over two envelope conformations in ...

The dimeric title compound, [Sm(2)(C(9)H(9)O(3))(6)(C(12)H(8)N(2))(2)], is centrosymmetric and is composed of six 2-phen-oxy-propionate anions and two 1,10-phenanthroline ligands. The Sm(III) atom is coordinated by two O atoms from two bridging anions, four O atoms from two chelating anions and the N atoms of the N-heterocycle in a distorted dodeca-hedral geometry.

It is well known that phenolate anions react with benzo[1,2-c]1,2,5-oxadiazole N-oxides (benzofuroxans) to afford phenazine N,N-dioxide derivatives. These are obtained through an heterocycle expansion process by reaction of the corresponding 1,2,5-oxadiazole system with the phenolate carbanion generated in basic medium attacking one of the heterocyclic nitrogen (Figure 1). When substituted benz...