BACKGROUND Genital herpes is epidemic in the United States; long-term acyclovir therapy is common; and long-term use of antimicrobials in suppressive doses favors development of resistance. OBJECTIVE To determine the prevalence of and risk factors for acyclovir-resistant genital herpes. METHODS We identified and attempted to enroll all patients 18 years or older with suspected genital herpe...

A sensitive enzyme linked immunosorbent assay (ELISA) was developed to evaluate the potential of herpes simplex virus (HSV) specific antibodies in the diagnosis of herpetic eye infection. The presence of HSV specific secretory IgA (sIgA) in tears was found to be diagnostic of infection. However, serum and tear HSV specific IgG and IgA were not considered reliable indicators of active infection.

Abstract: Peganum harmala L. (Zygophylaceae) has been used in a variety of practical applications in medical science. Our objective in the current study was to determine the effects of the seed extract on Herpes simplex virus type 1 (HSV-1) replication in Vero cells. Different concentrations (100, 500, 571, 667, 800 and 1000 µg/ml) of the extract were examined. Experiments were carried ...

Subjects with oral herpes lesions at the time of serum sampling had higher-efficiency antibody (higher proportion of neutralizing antibody as determined by plaque reduction, compared with total antibody as detected by radioimmunoassay) to herpes simplex virus type 1 (HSV-1) than did subjects with no lesions at the time of serum sampling. These higher-efficiency sera also had higher antibody tit...

The immunology of herpes simplex infections has been reviewed, part icularly in relation to potential herpes simplex virus (HSV) vaccines, and to the association between HSV and cervical cancer. Relevant data from humans, experimental animals, and in v i t r o systems implicate both specific immune mechanisms and nonspecif ic factors in the course of HSV infections. There appear to be complex i...

Background and Aims: Herpes simplex virus (HSV) is responsible for several significant human viral diseases, with severity ranging from subclinical to fatal infection. Herpes simplex virus type 2 (HSV2) infections are more commonly seen in association with the genitalia and surrounding areas, and can be transmitted to newborns during childbirth. Generalized infections in newborns are also predo...

The immunology of herpes simplex infections has been reviewed, particularly in relation to potential herpes simplex virus (HSV) vaccines, and to the association between HSV and cervical cancer. Relevant data from humans, experimental animals, and in vitro systems implicate both specific immune mechanisms and nonspecific factors in the course of HSV infections. There appear to be complex interac...

The interaction of Herpes Simplex Virus type 1 (HSV-1) with human fetal foreskin fibroblast (HFFF) cell was studied using a recent isolate of HSV-1 which was propagated in Hep-2 cells. HFFF cells were challenged with HSV-1 with a multiplicity of infection (MOI) of 1 virus/cell for 24 hours. Flow cytometric analysis demonstrated that HSV-1 challenged HFFF cells expressed increased levels of α2β1...

The immunology of herpes simplex infections has been reviewed, part icularly in relation to potential herpes simplex virus (HSV) vaccines, and to the association between HSV and cervical cancer. Relevant data from humans, experimental animals, and in v i t r o systems implicate both specific immune mechanisms and nonspecif ic factors in the course of HSV infections. There appear to be complex i...

OBJECTIVE To review the ages of patients with recurrent herpes simplex virus type 2 (HSV-2) meningitis. DESIGN Case report and literature review back to 1970. SETTING Referral Veterans Affairs hospital. RESULTS Our patient developed his first episode of recurrent HSV-2 meningitis at 78 years of age, 57 years after his only episode of genital herpes simplex infection. Of 223 patients in th...