Carpesium abrotanoides L. is rich in sesquiterpene lactones, the experiments of anti-tumor activity vitro showed that total lactone extracts exhibited most cytotoxicity activities against HepG-2 cells (IC50 = 4.2 μg/mL). In order to isolated active compounds quickly, strategy HPLC-ESI-Q-TOF-MS/MS combined with high-speed counter-current chromatography (HSCCC) was implemented. Three compounds, 2...

Abstract In this work, new chitosan-based Schiff bases were synthesized by the reaction of chitosan with quinolinone and pyranoquinolinone giving CSQ , CSP respectively. The novel Chitosan grafted on silver nanoparticles providing CSQ/Ag CSP/Ag structures. Characterization isolated compounds was carried out FT-IR, TGA, XRD, SEM, TEM. target evaluated as antitumor agents against three cancer cel...

A new 1D Ni(II) coordination polymer was synthesized by the reaction of NiSO4·6H2O with 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (BPT) and SCN− as a linker in an acidic medium heating under reflux conditions. Unusually, BPT ligand underwent acid-mediated hydrolysis losing one pyrazolyl arms afforded polymeric [Ni(MPT)(H2O)(SCN)2]n complex (MPT: 4-(3,5-dimethyl-1H-pyrazol-1...

Abstract Coumarin and its nitrogen analogue 1-aza coumarin are a class of lactones lactams, respectively, which indispensable heterocyclic units to both chemists biochemists. 1-Aza derivatives, ultimately metabolize as the corresponding 8-hydroxy coumarins in biological system therefore found be very good anti-inflammatory, anti-cancer, analgesic agents. A series hybrid substituted azacoumarin-...

Sesquiterpenoid tagitinin C, present in Tithonia diversifolia leaves, has been known to have anti-hepatoma properties. Therefore, we investigated the anti-metastatic potential of C xenograft models hepatocellular carcinoma (HCC). We isolated from a methanolic extract leaves T. diversifolia. HepG-2 and Huh 7 hepatoma cells were treated with cell viability, migration, matrix metalloproteinase (MP...

iran has 1260 km of coastline that borders the persian gulf and the oman sea in the northwest indian ocean. marine algae are one of the natural resources in the marine ecosystem which produce a wide range of new secondary metabolites with various biological activities that play an important role in the pharmaceutical care. in this study the cytotoxic activity of 28 marine algae of chabahar coas...

Sophora interrupta Bedd, was a common woody perennial herb native to India. Reports suggest that the plant possesses numerous health promoting benefits such as anticancer, antiinflammatory, antimicrobial and antioxidant activities. The plant exhibited several potential in vitro anticancer effects on MCF-7, PC-3, HeLa and HePG-2 cell lines. In vivo assay’s suppressed in mouse models Dalton’s lym...

A (pyridazinyl)acetate derivative was reacted with thiosemicarbazide and hydrazine hydrate to yield spiropyridazinone and acetohydrazide derivatives, respectively. The acetohydrazide derivative was used as a starting material for synthesizing some new heterocyclic compounds such as oxoindolinylidene, dimethylpyrazolyl, methylpyrazolyl, oxopyrazolyl, cyanoacetylacetohydrazide and oxadiazolylacet...

Cancer is a major cause of death worldwide and causes serious problems in human life. It is developed by uncontrolled growth of a cell or a group of cells. There are many difficulties in treatment of cancer and many researchers are involved in investigating for effective drugs to treat the disease. Caryophyllaceae is a large family of about 86 genera and 2200 herbaceous or subshrub species. The...