نتایج جستجو برای: hepcidin

تعداد نتایج: 2675  

Journal: :The American journal of tropical medicine and hygiene 2007
Caitlin T Howard Uri S McKakpo Isabella A Quakyi Kwabena M Bosompem Ebenezer A Addison Kai Sun David Sullivan Richard D Semba

The pathogenesis of malarial anemia is incompletely understood. Hepcidin, a recently discovered peptide hormone, is a major regulator of iron metabolism and is thought to play a central role in the anemia of chronic inflammation. The specific aim of the study was to characterize the association between urinary hepcidin, hemoglobin, and parasitemia in 199 patients presenting for evaluation of Pl...

2012
Inge Geerts Pieter Vermeersch Etienne Joosten

Introduction. Anemia is a frequent problem in hospitalized geriatric patients, and the anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the 2 most prevalent causes. The aim of the study was to assess the possible role of serum hepcidin in the differential diagnosis between ACD and IDA. Methods. We investigated serum hepcidin, iron status, anemia, and C-reactive protein in 39...

Journal: :Cell metabolism 2005
Rui-Hong Wang Cuiling Li Xiaoling Xu Yin Zheng Cuiying Xiao Patricia Zerfas Sharon Cooperman Michael Eckhaus Tracey Rouault Lopa Mishra Chu-Xia Deng

Hereditary hemochromatosis, characterized by iron overload in multiple organs, is one of the most common genetic disorders among Caucasians. Hepcidin, which is synthesized in the liver, plays important roles in iron overload syndromes. Here, we show that a Cre-loxP-mediated liver-specific disruption of SMAD4 results in markedly decreased hepcidin expression and accumulation of iron in many orga...

Journal: :The Journal of clinical investigation 2007
Ivana De Domenico Diane M Ward Jerry Kaplan

Hepcidin is a peptide hormone secreted by the liver that plays a central role in the regulation of iron homeostasis. Increased hepcidin levels result in anemia while decreased expression is the causative feature in most primary iron overload diseases. Mutations in hemochromatosis type 2 (HFE2), which encodes the protein hemojuvelin (HJV), result in the absence of hepcidin and an early-onset for...

Journal: :The Journal of infectious diseases 2009
Quirijn de Mast Behzad Nadjm Hugh Reyburn Erwin H J M Kemna Ben Amos Coby M M Laarakkers Simphorosa Silalye Hans Verhoef Robert W Sauerwein Dorine W Swinkels Andre J A M van der Ven

Disturbances in iron homeostasis are frequently observed in individuals with malaria. To study the effect of malaria and its treatment on iron homeostasis and to provide a mechanistic explanation for observed alterations in iron distribution, we studied the course of the iron regulatory hormone hepcidin in anemic Tanzanian children with febrile Plasmodium falciparum malaria. Before initiation o...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Ivana De Domenico Eric Lo Diane M Ward Jerry Kaplan

Hepcidin is a hormone secreted in response to iron loading and inflammation. Hepcidin binds to the iron exporter ferroportin, inducing its degradation and thus preventing iron entry into plasma. We determined that hepcidin binding to ferroportin leads to the binding and activation of the protein Janus Kinase2 (Jak2), which is required for phosphorylation of ferroportin. Ferroportin is a dimer a...

Journal: :Haematologica 2008
Junya Kanda Chisaki Mizumoto Hiroshi Kawabata Hideyuki Tsuchida Naohisa Tomosugi Keitaro Matsuo Takashi Uchiyama

The relationship between serum hepcidin, a key regulator of body iron homeostasis, and erythropoiesis was investigated before and after stem cell transplantation in 31 patients with hematopoietic malignancies. Serum hepcidin-25 was monitored using a liquid chromatography-tandem mass spectrometry-based assay system. Other iron- and erythropoiesis-related parameters and known hepcidin regulators,...

2018
Driton Vela

Liver fibrosis is a precursor of liver cirrhosis, which is associated with increased mortality. Though liver biopsy remains the gold standard for the diagnosis of fibrosis, noninvasive biochemical methods are cost-effective, practical and are not linked with major risks of complications. In this respect, serum hepcidin, has emerged as a new marker of fibrosis and cirrhosis. In this review the d...

Journal: :Haematologica 2009
Sara Pelucchi Raffaella Mariani Paola Trombini Sabina Coletti Matteo Pozzi Valentina Paolini Donatella Barisani Alberto Piperno

Transferrin receptor-2 (TFR2) regulates hepatic hepcidin secretion and when mutated causes type-3 hemochromatosis. No functional study is available in humans. We studied a 47 year-old woman with hemochromatosis. TFR2 DNA and its hepatic transcript were directly sequenced. Hepatic expression of hepcidin and other iron-related genes were measured by qRT-PCR. Urinary hepcidin was measured at basel...

2017
Sandra L. Ross Kaustav Biswas James Rottman Jennifer R. Allen Jason Long Les P. Miranda Aaron Winters Tara L. Arvedson

The iron exporter ferroportin and its ligand, the hormone hepcidin, control fluxes of stored and recycled iron for use in a variety of essential biochemical processes. Inflammatory disorders and malignancies are often associated with high hepcidin levels, leading to ferroportin down-regulation, iron sequestration in tissue macrophages and subsequent anemia. The objective of this research was to...

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