caffeic acid phenethyl ester(cape) suppresses the growth of transformed cells such as human breast cancer cells, hepatocarcinoma , myeloid leukemia, colorectal cancer cells, fibrosarcoma, glioma and melanoma. a group of heterocyclic esters of caffeic acid was synthesized using mitsunobu reaction and the esters were subjected to further structural modification by electrooxidation of the catechol...

pyrazine derivatives are important class of compounds with diverse biological and cytotoxic activities and clinical applications. in this study, b3 p 86 / 6 – 31 + + g * was used to compute and map the molecular surface electrostatic potentials of a group of substituted amides of pyrazine-2-carboxylic acids to identify common features related to their subsequent cytotoxicities. several statisti...

the complex metabolic syndrome, diabetes mellitus, is a major human health concern in the world and is estimated to affect 300 million people by the year 2025. several drugs such as sulfonylureas and biguanides are presently available to reduce hyperglycemia in diabetes mellitus. these drugs have side effects and thus searching for a new class of compounds is essential to overcome this problems...

the whole plant, pergularia daemia (family: asclepediaceae), was extracted with 50% alcohol and a fresh batch of the plant material was successively extracted with petroleum ether, ethyl acetate and n-butanol to determine its diuretic activity. the diuretic activity of the different extracts at a dose of 400 mg/kg was assessed orally in rats with furosemide as a standard drug using lipschitzs t...

background: recent studies have shown that physical activity is an effective factor in improving sleep quality. therefore, this study aimed to compare the sleep quality of athlete and non-athlete pregnant women. methods: this cross-sectional descriptive analytical study was performed on 300 pregnant women in the last trimester of pregnancy, referred to prenatal care unit of amiralmomenin hospit...

the ethanolic extract of ficus carica leaves was screened for hepatoprotective and antioxidant activity in hepatotoxic albino rats induced via carbon tetrachloride. the degree of protection was measured by estimating biochemical parameters such as serum glutamate oxaloacetate transaminase (sgot), serum glutamate pyruvate transaminase (sgpt), total protein (tp), total albumin (ta), alkaline phos...

the aim of this study was to evaluate the effect of walnut tree root (juglandaceae) on escherichia coli is resistant to various antibiotics. walnut tree root extract was obtained using a rotary device. 20 cases of e. coli was obtained from urinary tract infections zabul hospital and mic and mbc were determined using dilution in the wells. the results of the study showed that the concentrations ...

background: mushroom tyrosinase a potent candidate in clinical studies known as polyphenol oxidase, is a metaloenzyme from the oxidase superfamily widely distributed from lower to higher life forms. it plays a crucial role in sclerotization of exoskeleton in insects, also responsible for skin pigmentation in mammalians. objective: in this study, after reconstitution of mt by some metal ions, th...

objective(s)                                                                                                                                                                               aim of the present study was to screen the antibacterial activities of some medicinal plants extracts traditionally used in azarbaijan area (iran). materials and methods thirty-six extracts obtained from differ...

background: systemic lupus erythematosus is a systemic autoimmune disorder with unclear etiology. the importance of some genes in the development of systemic lupus erythematosus has been implicated. the gene polymorphism in codon 72 has attracted a lot of attention and its role in the occurrence or progression of many cancers and autoimmune diseases especially systemic lupus erythematosus has b...