In the present study, the hepatoprotective activity of ethanolic extracts of Cassia sophera Linn. leaves was evaluated against carbon-tetrachloride- (CCl(4)-) induced hepatic damage in rats. The extracts at doses of 200 and 400 mg/kg were administered orally once daily. The hepatoprotection was assessed in terms of reduction in histological damage, changes in serum enzymes, serum glutamate oxal...

Mammea africana Sabine (Guttiferae) stembark, a common plant, traditionally used to treat various diseases and ailments was evaluated for hepatoprotective potentials against paracetamol- induced liver injury in rats. The hepatoprotective effect of the stembark extract (30-90 mg/kg) was evaluated by the assay of liver function parameters: total and direct bilirubin, serum protein and albumin, to...

Objective: To evaluate the hepatoprotective activity of Pterocarpus marsupium stem bark extracts against carbon tetrachloride (CCl 4 )-induced hepatotoxicity. Materials and methods: Hepatotoxicity was induced in male Wistar rats by intraperitoneal injection of CCl 4 (0.1 ml/kg/day for 10 days). Methanol and aqueous extracts of P. marsupium stem bark were administered to the experimental rats (2...

Navayasa curna mixed in Lohasava was screened for hepatoprotective activity against carbon tetrachloride induced liver injury in albino rats at a dose of 100mg/kg body weight. The drug reduced liver weight, alkaline phosphatase and GOT activity in liver and chloresterol and GPT activity in serum. There was no effect on protein and liver glycogen.

Objective: To evaluate the hepatoprotective activity of crude aqueous and ethanol stem bark extracts of Pterocarpus santalinus (Fabaceae) using CCl 4 induced hepatic damage in male Wistar albino rats. Department of Botany, Materials and Methods: The aqueous (45 mg/ml) and ethanol (30 mg/ml) extracts of S.R.N.M.N. College of Applied stem bark in 1% gum tragacanth was administered orally for 14 d...

Activated hepatic stellate cells (HSCs) are the main extracellular matrix (ECM)-producing cells in the injured liver and the key mediators of liver fibrosis; they also promote the progression of hepatocellular carcinoma (HCC). In the acidic extracellular microenvironment of HCC, HSCs are activated to promote the migration of HCC cells. It is worth attempting to alter the weak acidic microenviro...

Introduction: Lagenaria siceraria has various pharmacological effects like antioxidant, anti-hyperglycemic, anti-ulcer, anti-cancer, hepatoprotective, antimicrobial, anti-hyperlipidemic, anti-inflammatory and cardioprotective activities is used to treat diseases diabetes, jaundice, piles, ulcers, hypertension, colitis, insanity, skin diseases.Context purpose of the study: The aim present study ...

BACKGROUND The liver plays an essential role in the body by regulating several important metabolic functions. Liver injury is associated with the distortion of these functions causing many health problems. Pharmaceutical drugs treat liver disorders but cause further damage to it. Hence, herbal drugs are used worldwide and are becoming increasingly popular. METHODS The hepatoprotective activit...

the ethanol extract of bacopa monnieri linn. (schrophulariaceae) aerial parts (ebm) was investigated for any in vitro and in vivo antioxidant and hepatoprotective effects. ebm was prepared and estimation of total phenolics was carried out. further, the antioxidant activity of ebm was studied using four in vitro models. the amount of total phenolics was estimated to be 47.7 (g of pyrocatechol eq...

The aim of this study was to evaluate pharmacological properties of ethanol extracted from Mahonia oiwakensis Hayata stems (MOS(EtOH)). The pharmacological properties included antioxidant, analgesic, anti-inflammatory and hepatoprotective effects. The protoberberine alkaloid content of the MOS(EtOH) was analyzed by high-performance liquid chromatography (HPLC). The results revealed that three a...