Six triterpene acids identified as betulinic, oleanolic, ursolic, 3-epimaslinic, alphitolic and euscaphic acids have been isolated from a dichloromethane extract of hairy root cultures of Ocimum basilicum L. (Lamiaceae). These cultures were obtained by genetic transformation using Agrobacterium rhizogenes. The extract as well as the isolated compounds were evaluated for their hepatoprotective a...

Goodyeroside A, a natural product isolated from the Goodyera species, possesses significant hepatoprotective activity and has a novel skeleton not previously observed in other synthetic drugs used for the treatment of hepatitis. Herein, we report a highly stereoselective synthesis of goodyeroside A and related analogs with varying substituents at the α position of the carbonyl group to explore ...

Background: Diethylnitrosamine (DEN) is a hepatotoxin whose metabolic activation by liver cytochromes P450 responsible for the necrosis, mutagenicity and carcinogenicity of cells. The purpose this study was to evaluate protective effects Calotropis procera roots bark against DEN induced hepatocellular damage in rats.
 Material Methods: Hepatoprotective activity ethanolic extract root were ...

BACKGROUND Palm kernel cake (PKC), the most abundant by-product of oil palm industry is believed to contain bioactive compounds with hepatoprotective potential. These compounds may serve as hepatoprotective agents which could help the poultry industry to alleviate adverse effects of heat stress on liver function in chickens. METHODS This study was performed to evaluate the hepatoprotective po...

BACKGROUND Traditional systems of medicine use herbal drugs for hepatoprotection. Thus, the study was designed to evaluate the hepatoprotective and antioxidant effects of Spondias pinnata bark extracts against ethanol-induced liver injury in Wistar rats. METHODS Group I animals were treated with 1 mL/kg 0.3% carboxymethyl cellulose and Group II with 12 mL/kg 50% ethanol for 8 consecutive days...

background: corn silk (cs) is widely used in iranian traditional medicine. the aim of this study was to investigate hepatoprotective activity of cs by isolated rat liver perfusion system (irlp). methods: hydro-alcoholic extract of corn silk (10, 20, 40, and 100 mg kg-1) was evaluated for its hepatoprotective activity by irlp. phenol and flavonoid contents of the extract were determined as galli...

objective: to evaluate the hepatoprotective properties of otostegia persica (o. persica) ethanol extract on carbon tetrachlo­­ride-induced liver damage in rats. materials and methods: fifty adult male wistar rats were randomly divided into five groups. group i served as normal control and was given only olive oil intraperitoneally (i.p.). group ii, iii, iv, and v were administered ccl4 mixed wi...

background: hyperthyroidism is associated with liver oxidative stress causing liver dysfunction in many hyperthyroid patients. the hepatoprotective effect of satureja khuzestanica essential oil (skeo), as herbal origin antioxidant and anti-inflammatory agent on the hyperthyroidism induced hepatotoxicity and oxidative stress is investigated. methods: adult male sprague dawley rats were divided i...

Lepidium sativum seed (LSS) (family: Cruciferae) has been used in traditional medicine for the treatment of jaundice, liver problems, spleen diseases and gastrointestinal disorders. It was also reported to possess antihypertensive, diuretic, anti-asthmatic, antioxidant, and anti-inflammatory activities. Attempt has been made to study hepatoprotective potential of LSS available in Saudi Arabian ...

BACKGROUND Coreopsis tinctoria is a traditional remedy for the management of various diseases including hepatitis. The hepatoprotective role of the plant is not scientifically explored till now. This study was designed to investigate the hepatoprotective potentials of the ethanol extract from C. tinctoria (CTEtOH) using an animal model of carbon tetrachloride (CCl4)-induced acute liver injury. ...