Detection and imaging of α-L-fucosidase (AFU) is great value to understand its roles in hepatocellular carcinoma (HCC) tumor early diagnosis, but ideal assays are still lacking. Herein, a near-infrared (NIR) fluorescent biosensor (α-Fuc-DCM) was elaborately designed synthesized for rapid ratiometric detection AFU activity cells HCC mouse models. In the presence AFU, this shows an enhancement NI...

objective(s): in this study, we aimed to describe the characteristics of portal vein tumor thrombosis (pvtt), complicating hepatocellular carcinoma (hcc) in contrast-enhanced fdg pet/ct scan. methods: in this retrospective study, 9 hcc patients with fdg-avid pvtt were diagnosed by contrast-enhanced fluorodeoxyglucose positron emission tomography/computed tomography (fdg pet/ct), which is a comb...

Background: Inflammatory cytokines are related to the occurrence and development of hepatocellular carcinoma (HCC). Objectives: Interleukin 6 (IL-6) is associated with prognosis HCC, while Dicer inhibits HCC; accordingly, we checked whether regulates HCC by modulating IL-6 pathway. Methods: The cells SMMC-7721 transfected overexpression (pCMV-Dicer) control (pCMV-NC) lentivirus were divided int...

BACKGROUND Numb is an evolutionary conserved protein that plays critical roles in cell fate determination, cell adhesion, cell migration and a number of signaling pathways, but evidence for a substantial involvement of Numb in HCC has remained unclear. The present study was aimed to investigate the clinical and prognostic significance of Numb and its role in hepatocellular carcinoma (HCC). ME...

Hepatocellular carcinoma (HCC) is a common tumor. Although the diagnosis and treatment of HCC have made great progress, overall prognosis remains poor. As core component artificial intelligence, machine learning (ML) has developed rapidly in past decade. In particular, ML become widely used medical field, it helped cancer. Different algorithms different roles diagnosis, treatment, prognosis. Th...

Among the four histopathological variants of hepatocellular carcinoma, Fibrolamellar carcinoma (FLHCC) is a rare variant (HCC). It occurs in less than 1 % cases with distinct features as compared to classical HCC. differs from typical HCC terms epidemiology, etiology, clinical presentation and prognosis. In this case report we are going present fibrolamellar variety 20-year young male no histor...

The prognosis of hepatocellular carcinoma (HCC) after surgery is poor due to its high recurrence rate. In order to unfold the mechanism of different recurrent-free survival (RFS) times following resection, expression profiling of tumor tissues from 32 HCC patients with different RFS time were used to identify differential expression of individual genes and signaling pathway components correlate...

Objective GP73 is a new hepatocellular carcinoma (HCC) marker, which is highly expressed in hepatocellular carcinoma and closely relates to prognosis. This study was to investigate the effects of GP73 on cellular proliferation, apoptosis, oxaliplatin (OXA) resistance and secretory clusterin (sCLU) of HCC cells. Materials and Methods Western blot and immunofluorescence was used to detect the exp...

Recently developing countries showing growing trend in hepatocellular carcinoma cases. Hepatocellular metastasis to oral cavity is uncommon finding. Most common site for mets lung, breast, kidney. Data on HCC limited. We present here one such rare case of cavity. Awareness about the entity helps early diagnosis and management that leads better prognosis good quality life patient.

Abstract T cell exclusion restricts immune checkpoint blockade (ICB) efficacy for some hepatocellular carcinoma (HCC) patients. Epigenetic therapy provides new opportunities to rewire transcriptional programs. We have recently elucidated that pharmacological inhibition of histone deacetylase 8 (HDAC8) resulted in increased CD8 +T infiltration and enhanced ICB HCC. Moreover, this combined immuno...