نتایج جستجو برای: hepatic nuclear factor 1 beta hnf1β
تعداد نتایج: 3656898 فیلتر نتایج به سال:
The early prediction of pregnancy-induced hypertension (PIH) is based on the demonstration of increased sympathetic activity in early part of pregnancy. However, the mechanisms that increase sympathetic activity in PIH have not yet been fully elucidated. Therefore, in the present study we have investigated the link of albumin-globulin ratio (AGR) to sympathovagal imbalance in PIH patients. Spec...
Murine hepatitis virus strain (MHV-3) produces a strain-dependent pattern of disease which has been used as a model for fulminant viral hepatitis. This study was undertaken to examine whether there was a correlation between macrophage activation and susceptibility or resistance to MHV-3 infection. Peritoneal macrophages were isolated from resistant A/J and susceptible BALB/cJ mice and, followin...
Posttransplantation diabetes mellitus (PTDM) is a frequent complication in immunosuppressive therapy. To better understand the molecular events associated with PTDM we investigated the effect of cyclosporine on expression and activity of hepatic nuclear factor (HNF)1alpha and 4alpha and on genes coding for glucose metabolism in cultures of the rat insulinoma cell line INS-1E, the human epitheli...
Recent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic cell types, but to date stem or progenitor cells have only been reprogrammed for the blood and neuronal lineages. We previously reported generation of induced hepatocyte-like (iHep) cells by transduction of Gata4, Hnf1α, and Foxa3 in p19 Arf null mouse embryonic fibroblasts (MEFs). Here, we show that Hn...
Apolipoprotein B (apoB) mRNA editing is a nuclear event that minimally requires the RNA substrate, APOBEC-1 and APOBEC-1 Complementation Factor (ACF). The co-localization of these macro-molecules within the nucleus and the modulation of hepatic apoB mRNA editing activity have been described following a variety of metabolic perturbations, but the mechanism that regulates editosome assembly is un...
Insulin production by beta-cells derived from hepatic oval cells is a promising new approach for the treatment of diabetes. Hepatic oval cells can be redirected to the beta-cell linage by an appropriate combination of high extracellular glucose, specific extracellular matrix proteins (laminin and fibronectin), cytokines (activin A), and the expression of several differentiation-related transcri...
Hepatobiliary transporters are down-regulated in toxic and cholestatic liver injury. Cytokines such as tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) are attributed to mediate this regulation, but their particular contribution in vivo is still unknown. Thus, we studied the molecular mechanisms by which Ntcp, Oatp1, Oatp2, and Mrp2 are regulated by proinflammatory cyt...
background: human embryonic stem cells (hesc), which are derived from the inner cell mass of the blastocysts, have been considered to be pluripotent cells. in this study we examine the differentiating potential of hesc into hepatocytes by characterization of the expression of endoderm and liver-specific genes. methods: hesc were cultivated in suspension to form aggregates, the embryoid bodies. ...
Submit Manuscript | http://medcraveonline.com Abbreviations: ARVO: Association for Research on Vision and Ophthalmology; BRB: Blood-Retina Barrier; DR: Diabetic Retinopathy; GAPDH: Glyceraldehydes 3-Phosphate Dehydrogenase; IL-1β: Interleukin-1 Beta; JNK: C-June Kinase; KO: Knock Out; NF k B: Nuclear Factor Kappa Beta; NG2: Neuroglial Antigen-2; NGF: Nerve Growth Factor, proNGF; Proform Of Nerv...
Submit Manuscript | http://medcraveonline.com Abbreviations: ARVO: Association for Research on Vision and Ophthalmology; BRB: Blood-Retina Barrier; DR: Diabetic Retinopathy; GAPDH: Glyceraldehydes 3-Phosphate Dehydrogenase; IL-1β: Interleukin-1 Beta; JNK: C-June Kinase; KO: Knock Out; NF k B: Nuclear Factor Kappa Beta; NG2: Neuroglial Antigen-2; NGF: Nerve Growth Factor, proNGF; Proform Of Nerv...
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