To investigate the reasons for the lack of sex differences in high density lipoproteins (HDL) observed in population studies of the Pima Indians, we selected 18 lean (9 men, 9 women, body mass index (BMI) less than 27) and 22 obese (12 men, 10 women, BMI greater than 27) Pima Indians for an inpatient study of HDL composition. We measured lipase activities and steroid hormone concentrations, bot...

It has been suggested previously that chlorpropamide and other hypoglycemic sulfonylureas interfere with hepatic triglyceride breakdown. Since ketogenesis from endogenous hepatic lipid stores is a measure of hepatic triglyceride hydrolysis, ketogenesis derived from endogenous lipids as well as ketogenesis derived from exogenously added isotopic oleate was determined in isolated hepatocytes from...

Background and Aims : Atherosclerotic cardiovascular disease is the main cause of mortality worldwide strongly influenced by plasma low-density lipoprotein cholesterol (LDL-C) levels. So far, only few genes with a strong causal relationship to LDL-C levels have been identified. Here, we aimed elucidate genetic origin an unexplained combined hypocholesterolemia inherited in four generations Fren...