نتایج جستجو برای: hent1

تعداد نتایج: 154  

1998
GAYATRI VASUDEVAN NICOLA S. CARTER MARK E. DREW STEPHEN M. BEVERLEY MARCO A. SANCHEZ ANDREAS SEYFANG BUDDY ULLMAN SCOTT M. LANDFEAR

All parasitic protozoa studied to date are incapable of purine biosynthesis and must therefore salvage purine nucleobases or nucleosides from their hosts. This salvage process is initiated by purine transporters on the parasite cell surface. We have used a mutant line (TUBA5) of Leishmania donovani that is deficient in adenosineypyrimidine nucleoside transport activity (LdNT1) to clone genes en...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2008
Michael P Kim Gary E Gallick

The diagnosis of pancreatic cancer confers a grim prognosis that has changed little over the last 30 years. Due to the lack of any efficacious screening or biomarkers for pancreatic cancer, presentation with advanced local disease is typical (classically, painless jaundice) and morbidity aside, 4% of patients are alive 5 years after the time of diagnosis. The nucleoside analogue gemcitabine, wh...

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