نتایج جستجو برای: hemoglobinopathy
تعداد نتایج: 519 فیلتر نتایج به سال:
Aims HbA1c can usually be used as the indicator of glucose control and correlated with the development of long-term diabetic complications. But there are limits that it usually reflects the mean glucose levels of 2-3 months and can be variable in the situation of hemoglobinopathy or the conditions of altered RBC lifespan. In contrast, serum fructosamine levels reflect the mean glucose levels of...
Sickle cell disease is hereditary hemoglobinopathy which causes haemolytic anemia, vaso-occlusive crisis, ischemic injuries and many other morbidities like cerebral infarction. In this report, we describe a case of a young patient with sickle cell disease presenting with right-sided weakness and slurring of speech with examination confirming right-sided hemiparesis with motor aphasia. On furthe...
Sickle cell disease (SCD) is an inherited hemoglobinopathy characterized by a wide range of clinical manifestations. Chronic leg ulcers are a disabling complication with repercussions on the quality of life. We report the case of a 14-year-old girl with a diagnosis of SCD who developed a chronic leg ulcer that was successfully treated with a multi-disciplinary approach, including local and syst...
OBJECTIVE Hemoglobin (Hb) S disorder [beta6(A3)Glu-->Val, GAG-->GTG] is an important hemoglobinopathy with the highest endemicity in Africa. METHODS Here, the author performs a basic bioinformatics gene ontology study to assess the effect of co-expression between nucleic acid sequence for human Hb S beta globin chain and U7.623. RESULTS According to this study, the analytical results show t...
A brief survey of abnormal hemoglobin variants among the major ethnic groups of Karachi was conducted; 202,600 subjects were studied. Patients with low hemoglobin (Hb), low mean cell volume (MCV) and mean cell hemoglobin (MCH) including anemia, microcytosis, hypochromic hemolysis and target cells, were refered for the identification of hemoglobinopathy by molecular methods. Population screening...
After its discovery as a genetically inherited hemoglobinopathy one hundred years ago, finding a widely available cure for sickle cell anemia (SCA, HbSS) still remains a challenge and the disease requires multi-disciplinary theranostic approaches (Menaa et al., 2013; Menaa, 2014). Indeed, more effort and resources to promptly find alternative therapeutics and/or adjuvants (e.g. nutraceutics) to...
Methaemoglobinaemia is a rare but potentially life-threatening hemoglobinopathy. It is characterized by cyanosis that is not responsive to oxygen therapy. We report a case of acute methaemoglobinaemia secondary to intentional dapsone overdose. A 34 year old lady presented to our institution with a history of sudden onset of dyspnoea. Her level of consciousness had reportedly deteriorated dramat...
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