The rab2 gene product belongs to the rab branch of the ras-related GTP-binding protein family. The rab2 gene mRNA analysis in 70 tumor samples from various origins showed no obvious difference between malignant tissues and their normal counterparts. However, an over-expression has been observed at the RNA or protein levels in peripheral blood mononuclear cells from the nine patients with Sézary...

background: the challenge of antiepileptic drugs (aeds) management is to attain the best compromise between the desire to maximize seizure control and the need to keep side‑effects within tolerable limits for the individual patient. to reduce devastation in iranian epileptic patients, the aim of this study was to explore the overall outcome following aeds prescription. methods: a cross‑sectiona...

introduction: cupping therapy (hejamat) is one of the therapeutic methods used in traditional medicine that it is still common in many of the contemporary societies. in spite of the progress of science, we have less information on the traditional and alternative medicine including cupping.   with the study of mechanism of action of cupping, it will be more convincing for the traditional medicin...

objective(s): this study aimed to determine the possible toxicity of cuo nanoparticles (nps) on oncorhynchus mykiss by evaluating hematological parameters.materials and methods: fish were sampled and treated in 4 aquariums containing the concentration ranges of 1, 5, 20 and 100 ppm of cuo nps. there was one control group (no cuo nps) and three replicates. the physicochemical properties of water...

Managing hematological disorders in a tropical country presents several unique diagnostic and management problems. Apart from the disease process, we need to be aware of infections that can exacerbate or mimic serious hematological problems. We present here a series of five patients with pre-existing hematological diseases who were infected by dengue virus. These cases highlight the need to kee...

Introduction: Clinical trials are important to inform decision making and improve outcomes for patients with lymphoma. Phase II designed determine if a new treatment has enough promising efficacy safety warrant further investigation in phase III trial. Randomized controlled have historically received the greatest consideration providing reliable evidence of drug's efficacy. However, Single Arm ...

Since low JAK2V617F allele burden (AB) has been detected also in healthy subjects, its clinical interpretation may be challenging in patients with chronic myeloproliferative neoplasms (MPNs). We tested 1087 subjects for JAK2V617F mutation on suspicion of hematological malignancy. Only 497 (45.7%) patients were positive. Here we present clinical and laboratory parameters of a cohort of 35/497 pa...

Previous studies concerning the association of malignancies and bullous pemphigoid (BP) have ended up in conflicting results. Therefore, we conducted a case-control study to investigate BP. The Finnish Care Register for Health was utilized identify patients diagnosed with At least three International Classification Diseases (ICD)-10 codes L12.0 were required inclusion. Four sex age matched cont...

background: metals such as iron, zinc, and copper are critical and necessary for the survival of all living organisms, whereas xenobiotic metals such as lead, cadmium, mercury, and arsenic have no known biologic role. any metals in high doses can have toxic effects. the aim of this work was to evaluate the hematological changes induced by lead as a toxic metal and characterize the potential eff...