cardiovascular disease remains the leading cause of morbidity and mortality in the united states and europe. in recent years, the understanding that regenerative processes exist at the level of the myocardium, has placed stem cell research at center stage in cardiology. a stem cell is a cell that has the ability to divide (self replicate) for indefinite periods often throughout the life of the ...

BACKGROUND AND OBJECTIVE We have recently assisted to an increasing scientific interest and a new research effort in the field of stem cell-based therapy. Since the late 1980s hematopoietic stem cells (HSC) have been used to set up therapeutic strategies for the treatment of solid tumors such as gynecological cancers. In this context, different approaches have been suggested and clinically inve...

For patients with hematologic malignancies at high risk of relapse who do not have matched donors, a suitable alternative stem cell source is the HLA-haploidentical 2 or 3-loci mismatched family donor who is readily available for nearly all patients. Transplantation across the major HLA barrier is associated with strong T-cell alloreactions, which were originally manifested as a high incidence ...

titers were controlled after each ABO-incompatible transfusion using standard laboratory techniques. In the case of O/A recipientdonor blood group constellation we started adsorption of recipients’ Anti-A with one or two units of A2-RBCs followed by transfusion of A1-RBCs with a higher number of A-antigens per RBC. Using the technique of in vivo adsorption of isoagglutinins recipients’ anti-A o...

Champlin and colleagues have elegantly summarized the concept of nonmyeloablative stem cell transplantation (NST), stressing the importance of this newly emerging procedure for the treatment of patients with life-threatening malignant hematologic and nonhematologic diseases. This review does not include a description of the safety and efficacy of NST for the treatment of many life-threatening n...

The stem cell inhibitor, macrophage inflammatory proteinla (MIP-la) or LD78, protects multipotent hematopoietic progenitors in murine models from the cytotoxic effects of chemotherapy. Clinical use of human MIP-la during chemotherapy could therefore lead to faster hematologic recovery and may allow dose intensification. We have also shown that human MIP-la causes the rapid mobilization of hemat...

Background: Low-level lasers are used for various medical applications including wound healing and hair loss treatment. Cell Therapy using skin stem cells could be a novel approach to hair transplantation. However, there is no study on the effect of low-level laser on the hair follicle stem cells. So, in this study, we investigated the effect of low level laser irradiation on viability and ROS ...