OBJECTIVES Although cervical cancer is one of the potentially most preventable malignancies, it is still fairly common. In settings with established screening programs, increased compliance is important for future reduction in cervical cancer incidence, but it is presently unclear how this can be effectively achieved. METHODS We conducted a randomized controlled trial including all 12,240 wom...

Recently, vitamin E has been proposed to protect against Adriamycin-induced cardiotoxicity. We studied contractile decline and ultramicroscopic alterations of the heart of rabbits chronically treated with Adriamycin up to a cumulative dose of 400 mg/sq m. High doses of vitamin E did not protect against the Adriamycin-induced development of severe contractile decline as evaluated by means of mea...

Considerable attention has recently been paid to the molecular biology, cell biology, and mutations of the mouse Steel (SI) and dominant white spotting (W; c-kit) loci, which respectively encode stem cell (SCF; also referred to as mast cell growth and kit ligand7-9) and its cognate cellular receptor tyrosine kinase.’O Mice with mutations at either of these loci have similar developmental defect...

Patients with Down syndrome (trisomy 21, T21) have hematologic abnormalities throughout life. Newborns frequently exhibit abnormal blood counts and a clonal preleukemia. Human T21 fetal livers contain expanded erythro-megakaryocytic precursors with enhanced proliferative capacity. The impact of T21 on the earliest stages of embryonic hematopoiesis is unknown and nearly impossible to examine in ...

BACKGROUND The current WHO classification of hematologic malignancies defines distinct entities of myeloid disorders based on the presence of recurrent cytogenetic abnormalities. Diagnostic clonal chromosomal abnormalities provide important prognostic information and are among the most important factors in predicting initial response to chemotherapy, duration of remission and overall survival. ...

By VILLIAM H. BELL, JACQUELINE J. \\IIANC, PAUL P. CARBONE, GEORGE BIuCIIEJI AND JEROME B. BLOCK T HE BIOLOGICAL ACTIVITY of cytosine arabinosid& (1-/3-D-arabinofuranosylcytosine hydrochloride) has included inhibition of the multiplication of both neoplastic cells in animal systems23 and of DNA viruses.4’ Megaloblastosis and abnormal mitotic figures in marrow aspirates have l)een associated wit...

Although reports of typical acute promyelocytic leukemia (APL) cases rarely mention dysplastic changes, this report concerns a rare case of APL with tri-lineage dysplastic changes resembling the characteristic features of myelodysplastic syndrome (MDS). The patient, a 77-year-old Japanese male, was diagnosed as having pancytopenia with hematologic morphological abnormalities comprising micro - ...

Cytogenetic analyses in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) have revealed a great number of non-random chromosome abnormalities. In many instances, molecular studies of these abnormalities identified specific genes implicated in the process of leukemogenesis. The more common chromosome aberrations have been associated with specific laboratory and clinical charact...

to report the oral findings, including dental anomalies, ectopic eruption of the maxillary permanent first molars and periodontal disease and soft tissue alterations, in a subject with apert syndrome. clinical and radiographic examination of a patient with apert syndrome, aged 21 years old, not previously submitted for orthodontic or orthognathic treatment. dental anomalies were present in a pa...

orofacial clefts, including cleft lip with or without cleft palate (cl (p)), are common congenital malformations, second only to clubfoot in frequency of occurrence. the epidemiology and genetics of this disorder have been studied extensively in various countries by several investigators. the objective of this study is to assess the epidemiology and some genetic aspects of orofacial clefting at...