The winged helix proteins constitute a subfamily within the large ensemble of helix-turn-helix proteins. Since the discovery of the winged helix/fork head motif in 1993, a large number of topologically related proteins with diverse biological functions have been characterized by X-ray crystallography and solution NMR spectroscopy. Recently, a winged helix transcription factor (RFX1) was shown t...

Protein-DNA interactions are involved in different cancer pathways. In particular, the DNA-binding domains of proteins can determine where and how gene regulatory regions are bound in different cell lines at different stages. Therefore, it is essential to develop a method to predict and locate the core residues on cancer-related DNA-binding domains. In this study, we propose a computational met...

We consider a unit speed curve α in Euclidean four-dimensional space E and denote the Frenet frame by {T,N,B1,B2}. We say that α is a slant helix if its principal normal vector N makes a constant angle with a fixed direction U . In this work we give different characterizations of such curves in terms of their curvatures. MSC: 53C40, 53C50

Catalytic ultra-fast helix induction and its static helicity memory in a poly(biphenylylacetylene) were achieved by using chiral ammonium salts, as reported Katsuhiro Maeda, Eiji Yashima, co-workers their Research Article (e202217020). The remarkable acceleration of the helix-induction rate accompanied strong amplification relies on crown-ether-like specific intermolecular complex formation two...

MOTIVATION In many proteins, helix-helix interactions can be critical to establishing protein conformation (folding) and dynamics, as well as determining associations between protein units. However, the determination of a set of rules that guide helix-helix interaction has been elusive. In order to gain further insight into the helix-helix interface, we have developed a comprehensive package of...

Abstract Since the emergence of Triple Helix, expansions to Quadruple, Quintuple, N-tuple helices, and models decomposing higher-order helices into multiple interrelated triple or two-layer have been proposed. Albeit presenting alternative conceptual frameworks these different Helix seem unsuited address internal boundaries institutional spheres university, industry, government. Addressing this...