the phenomenon of " hormesis ". Exposure of organisms to mild stress fortifies them against subsequent, more severe insults. Yet, the relevant molecular mechanisms remain poorly understood. Although heat stroke is often fatal and survivors may suffer permanent neurologic damage, the mechanisms underlying heat stroke-induced cell and tissue injury remain elusive. To gain insight, we employed the...

BACKGROUND Severe heat stroke tends to be complicated with rhabdomyolysis, especially in patients with exertional heat stroke. Rhabdomyolysis usually occurs in the acute phase of heat stroke. We herein report a case of heat stroke in a patient who experienced bimodal rhabdomyolysis in the acute and recovery phases. CASE PRESENTATION A 34-year-old male patient was found lying unconscious on th...

INTRODUCTION We report the case of a patient who developed a severe post-exertional heat stroke with consecutive multiple organ dysfunction resistant to conventional antipyretic treatment, necessitating the use of a novel endovascular device to combat hyperthermia and maintain normothermia. METHODS A 38-year-old male suffering from severe heat stroke with predominant signs and symptoms of enc...

BACKGROUND Whereas hypotension and bradycardia seen during the onset of heatstroke may be protected by prior induction of heat shock protein 70 (HSP70) in the brain, the underlying mechanism is not fully understood. We evaluated the hypothesis that HSP70 may confer cardiovascular protection during heatstroke by potentiating the baroreceptor reflex (BRR) control of peripheral hemodynamic perform...

There is much interest in the association between exposures over the life course and risk of later disease. Attained adult height is determined by both genetic potential and growth in childhood. The latter is a useful marker of childhood circumstances, and consequently if associations between adult height and stroke are found they provide support for the hypothesis that exposures acting in chil...

Heat illness is a major source of injury for military populations in both deployed and training settings. Developing tools to help leaders enhance unit performance while reducing the risk of injury is of paramount importance to the military. Here, we review our recent systems biology approaches to heat stress in order to develop a 3-dimensional (3D) realistic thermoregulation model, identify th...

The present study aimed to investigate the protective effect of Xuebijing injection (XBJ) on lung injury in heat-stroke rats and the underlying mechanisms. In total, 54 rats were randomly assigned to non-thermal, saline vehicle and XBJ groups. The rectal temperature (Tc), mean arterial pressure (MAP) and respiratory rate (RR) of the rats were recorded. The time-point of heat stroke and the time...

BACKGROUND Patients with acute heat illness present primarily to emergency departments (EDs), yet little is known regarding these visits. OBJECTIVE We aimed to describe acute heat illness visits to U.S. EDs from 2006 through 2010 and identify factors associated with hospital admission or with death in the ED. METHODS We extracted ED case-level data from the Nationwide Emergency Department S...

Background: Heat stroke results in multiorgan failure and CNS injury. There a few case reports in the literature on the neurological consequences of heat stroke. Case Presentation: We describe a patient with heat stroke presenting with encephalopathy and bilateral cerebral, cerebellar, and thalamic lesions and intraventricular hemorrghage on MRI. Conclusion: Heat stroke should be in the differe...