نتایج جستجو برای: heat shock proteins hsp

تعداد نتایج: 813639  

2014
YONG-JOON CHOI NAM HO KIM MAN SUP LIM HEE JAE LEE SUNG SOO KIM WANJOO CHUN

Although selective striatal cell death is a characteristic hallmark in the pathogenesis of Huntington's disease (HD), the underlying mechanism of striatal susceptibility remains to be clarified. Heat shock proteins (HSPs) have been reported to suppress the aggregate formation of mutant huntingtin and concurrent striatal cell death. In a previous study, we observed that heat shock transcription ...

2014
Fumihiro Ito Takayuki Tamiya Iwao Ohtsu Makoto Fujimura Fumiyasu Fukumori

Molecular chaperones function in various important physiological processes. Null mutants of genes for the molecular chaperone ClpB (Hsp104), and those that encode J-domain proteins (DnaJ, CbpA, and DjlA), which may act as Hsp40 co-chaperones of DnaK (Hsp70), were constructed from Pseudomonas putida KT2442 (KT) to elucidate their roles. The KTΔclpB mutant showed the same heat shock response (HSR...

Journal: :American journal of physiology. Cell physiology 2006
Angela L Morrison Martin Dinges Kristen D Singleton Kelli Odoms Hector R Wong Paul E Wischmeyer

Glutamine (GLN) has been shown to protect cells, tissues, and whole organisms from stress and injury. Enhanced expression of heat shock protein (HSP) has been hypothesized to be responsible for this protection. To date, there are no clear mechanistic data confirming this relationship. This study tested the hypothesis that GLN-mediated activation of the HSP pathway via heat shock factor-1 (HSF-1...

Journal: :The Journal of biological chemistry 1990
M J Blake D Gershon J Fargnoli N J Holbrook

Although the induction of heat shock proteins (HSP) has been studied extensively in cultured cells, comparatively few studies have examined their expression in vivo. In this report, mRNA expression of two HSP families, HSP70 and HSP27, was investigated in brain, liver, lung, and skin of rats exposed to elevated ambient temperatures. The time course and relative magnitude of the heat-induced exp...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1985
C M Morganelli E M Berger H R Pelham

Hybrid genes containing the 5' region of Drosophila heat shock protein (hsp) genes, ligated to the herpesvirus thymidine kinase (tk) gene, were transfected into Drosophila line S3 cells. Constructions containing sequences upstream from hsp70, or from any of the small hsp genes, showed heat-inducible tk expression. Ecdysterone-inducible tk expression was seen only in transfections with small hsp...

Journal: :Circulation research 1998
I J Benjamin D R McMillan

How a cell responds to stress is a central problem in cardiovascular biology. Diverse physiological stresses (eg, heat, hemodynamics, mutant proteins, and oxidative injury) produce multiple changes in a cell that ultimately affect protein structures and function. Cells from different phyla initiate a cascade of events that engage essential proteins, the molecular chaperones, in decisions to rep...

1998
Randy McMillan Ivor J. Benjamin D. Randy McMillan

How a cell responds to stress is a central problem in cardiovascular biology. Diverse physiological stresses (eg, heat, hemodynamics, mutant proteins, and oxidative injury) produce multiple changes in a cell that ultimately affect protein structures and function. Cells from different phyla initiate a cascade of events that engage essential proteins, the molecular chaperones, in decisions to rep...

2000
YASUAKI MIZUSHIMA PING WANG DORAID JARRAR WILLIAM G. CIOFFI IRSHAD H. CHAUDRY Ping Wang Doraid Jarrar William G. Cioffi Irshad H. Chaudry

Mizushima, Yasuaki, Ping Wang, Doraid Jarrar, William G. Cioffi, Kirby I. Bland, and Irshad H. Chaudry. Preinduction of heat shock proteins protects cardiac and hepatic functions following trauma and hemorrhage. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R352– R359, 2000.—Although studies have shown that induction of the heat shock proteins (HSPs), such as HSP-70, has various be...

2011
Carmen Serrano Rosa Bolea Jaber Lyahyai Hicham Filali Luis Varona Ane Marcos-Carcavilla Cristina Acín Jorge H Calvo Magdalena Serrano Juan J Badiola Pilar Zaragoza Inmaculada Martín-Burriel

Heat shock proteins (Hsp) perform cytoprotective functions such as apoptosis regulation and inflammatory response control. These proteins can also be secreted to the extracellular medium, acting as inflammatory mediators, and their chaperone activity permits correct folding of proteins and avoids the aggregation of anomalous isoforms. Several studies have proposed the implication of Hsp in prio...

2000
P. Verbeke

Intracellular and extracellular proteins are subject to a variety of spontaneous non-enzymatic modi®cations which affect their structure, function and stability. Protein oxidation and glycation are tightly linked and are implicated in the development of many pathological consequences of aging. Although multiple endogenous pathways in the cell can prevent the formation of oxidized and glycated p...

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