The mechanisms of mitochondrial proton (H+) leak under various pathophysiological conditions are poorly understood. In the present study it was hypothesized that different mechanisms underlie H+ leak in cardiac IR (ischaemia/reperfusion) injury and IPC (ischaemic preconditioning). Potential H(+) leak mechanisms examined were UCPs (uncoupling proteins), allosteric activation of the ANT (adenine ...

Refrigeration service personnel have used leak detection equipment for years when servicing refrigeration equipment. In the past, leak detection typically was only concerned with leak pinpointing, either with an ultrasonic device, soap bubbles, dyes, thermal conductivity, or other electronic devices. Today, refrigerant leak detectors exist not only for pinpointing leaks, but also for monitoring...

PURPOSE To assess whether the presence and duration of air leaks after lobectomy are associated with an increased incidence of cardiopulmonary complications. METHODS Propensity score analysis was used on 726 patients undergoing pulmonary lobectomy from 1995 through 2004 to form three well-matched pairs of patients: patients with prolonged air leak (PAL) [> 7 days] and without air leak; patien...

BACKGROUND Double lumen dialysis catheters are routinely heparin or citrate 'locked' to maintain patency. Heparin lock-related bleeding episodes and antibiotic lock-related toxicity have been reported. The aim of this study is to quantify the amount of leak during 'lock' procedures and to compare leakage for different double lumen dialysis catheters. METHODS In an experimental, in vitro study...

With the growing footprint of solid oxide fuel cell stacks, there is a need to extend the operating range of compressible gaskets towards lower stress levels. This article describes a method to manufacture SOFC seals by coating a compressible sealing material (Thermiculite 866) with glass to obtain good sealing performance even at compression stresses as low as 0.1 MPa. Glass layer can be coate...

This paper will give an introduction to the leak detection of vacuum systems. Various methods to detect leaks as well as the most widely used helium leak detectors and their different applications are presented. Practical examples in the context of accelerator vacuum systems will illustrate the topic.

Leak detection is a very important step in the production and maintenance of oil and gas pipelines. It is needed to check tightness specifications and to ensure other installation specifications are fulfilled. In this paper some pipeline leak detection methodologies are studied to come up with a design structure that could ease pipeline leak detection and monitoring via Google earth. A common d...

BACKGROUND The effects of epidural needle design, angle, and bevel orientation on cerebrospinal fluid leak after puncture have not been reported. The impact of these factors on leak rate was examined using a dural sac model. Dural trauma was examined using scanning electron microscopy. METHODS Human cadaveric dura, mounted on a cylindrical model, was punctured with epidural needles using a mi...