Very low energy diets have been used clinically as an aid to weight loss in gross obesity.' The recent more general availability ofsuch diets has enabled them to be used without medical supervision by people with moderate to minimal obesity. The present case illustrates an interesting though rare manifestation of very low energy intake; indeed, low energy, low carbohydrate diets were advocated ...

A recent issue of the British Journal of Nutrition reflects a marked change in the importance we now attach to the role of dietary carbohydrates in both managing and retarding the development of non-communicable diseases, with four commentaries: Choosing your carbohydrates to prevent diabetes (Mathers, 2002); Low carbohydrate does not mean low glycaemic index! (Wolever, 2002); Diet, satiety and...

Current nutritional approaches to metabolic syndrome and type 2 diabetes generally rely on reductions in dietary fat. The success of such approaches has been limited and therapy more generally relies on pharmacology. The argument is made that a re-evaluation of the role of carbohydrate restriction, the historical and intuitive approach to the problem, may provide an alternative and possibly sup...

BACKGROUND Low-carbohydrate diets remain popular despite a paucity of scientific evidence on their effectiveness. OBJECTIVE To compare the effects of a low-carbohydrate, ketogenic diet program with those of a low-fat, low-cholesterol, reduced-calorie diet. DESIGN Randomized, controlled trial. SETTING Outpatient research clinic. PARTICIPANTS 120 overweight, hyperlipidemic volunteers from...

In this study, goldfish demonstrate preference for high carbohydrate and high fat diets, with no preference shown for high protein diets. Fish fed high (45% and 55%) carbohydrate (CHO) diets for 1 and 4 weeks exhibited decreased NPY gene expression in telencephalon-preoptic area (TEL-POA) and optic tectum-thalamus (OT-THAL) compared to fish fed low CHO (35% and 40%) diets. In hypothalamus (HYP)...

Non-alcoholic fatty liver disease (NAFLD) covers a spectrum of disorders ranging from simple steatosis (non-alcoholic fatty liver, NAFL) to non-alcoholic steatohepatitis (NASH) and cirrhosis. NAFL increases the risk of liver fibrosis. If the liver is fatty due to causes of insulin resistance such as obesity and physical inactivity, it overproduces glucose and triglycerides leading to hyperinsul...

BACKGROUND Protein supplementation has been shown to reduce the increases in intrahepatic triglyceride (IHTG) content induced by acute hypercaloric high-fat and high-fructose diets in humans. OBJECTIVE To assess the effect of a 12-wk iso-energetic high protein-low carbohydrate (HPLC) diet compared with an iso-energetic high carbohydrate-low protein (HCLP) diet on IHTG content in healthy non-o...