To design new compounds suitable as starting points for anticancer drug development, we have synthesized a novel series of benzoxazoles with pharmaceutically advantageous piperazine and fluorine moieties attached to them. The newly synthesized benzoxazoles and their corresponding precursors were evaluated for cytotoxicity on human A-549 lung carcinoma cells and non-cancer HepaRG hepatocyes. Som...

Phenolic compounds were measured in leaf tissues of apple cvs Jonagold and Golden Delicious, healthy and infected by Venturia inaequalis. Leaves were sampled from May to September 2005 and analyzed by high performance liquid chromatography. Hydroxycinnamic acids detected were chlorogenic, caffeic, ferulic and pcoumaric. In addition, the presence was ascertained of the dihydrochalcone phloridzin...

Many healthy subjects and patients are taking natural bioactive products for the prevention and treatment of multiple conditions, including gastrointestinal disorders. Based on current evidence, the scientific validity of the use of many of these commercial compounds by the general public is severely limited, with quality control and regulatory issues continuing to be a concern. Nevertheless, t...

PURPOSE Evidence suggests that healthy lifestyles may help maintain cognitive health. The Prevention Research Centers Healthy Aging Research Network, 9 universities collaborating with their communities and the Centers for Disease Control and Prevention, is conducting a multiyear research project, begun in 2005, to understand how to translate this knowledge into public health interventions. DE...

OBJECTIVE Chronic conditions such as cardiovascular disease and cancer can result from a number of diet-related environmental and behavioral factors. Screening for poor diet is helpful in developing interventions to prevent chronic disease, but measuring dietary behavior can be costly and time-consuming. The purpose of this study was to test the ability of a self-rated, single-item measure for ...

PWE-005 Table 1 Anal sphincter Range Median Resting pressure 30e163 cm H2O 109 cm H2O Cough pressure increase 39e305 cm H2O 143 cm H2O Voluntary squeeze pressure 50e922 cm H2O 275 cm H2O Endurance squeeze time 18e125 s 52 s % of relaxation during pushdown 0e42% (17/20 relaxed) 14% Competing interests None declared. REFERENCES1. Jones MP, Post J, Crowell MD. High-resolution manometry in the ...

THE FOOD, SOCIAL, HEALTH, AND LIVING ENVIRONMENTS IN WHICH PEOPLE MAKE DECISIONS HAVE A HUGE INFLUENCE ON NUTRITIONAL STATUS (FIGURE 6.1). For optimal nutrition, these underlying factors matter. For example, the food environment should make healthy diets available, affordable, accessible, and desirable. The social environment should set norms about good nutrition and hygiene and support people ...

We present findings from a field experiment conducted at 40 elementary schools involving 8000 children and 400,000 child-day observations, which tested whether providing short-run incentives can create habit formation in children. Over a 3- or 5-week period, students received an incentive for eating a serving of fruits or vegetables during lunch. Relative to an average baseline rate of 39%, pro...

Diabetes is a serious issue for African American women. The purpose of this project was to develop and test the feasibility of a culturally appropriate and faith-based healthy eating program for African American women at risk for developing diabetes. At total of 30 women from two churches completed a 12-week, faith-based program using a community-based approach with lay health educators in the ...