ANCHOR is a web-based tool whose aim is to facilitate the analysis of protein-protein interfaces with regard to its suitability for small molecule drug design. To this end, ANCHOR exploits the so-called anchor residues, i.e. amino acid side-chains deeply buried at protein-protein interfaces, to indicate possible druggable pockets to be targeted by small molecules. For a given protein-protein co...

BACKGROUND Patients with paroxysmal nocturnal hemoglobinuria harbor clonal glycosylphosphatidylinositol-anchor deficient cells arising from a multipotent hematopoietic stem cell acquiring a PIG-A mutation. Many patients with aplastic anemia and myelodysplastic syndromes also harbor small populations of glycosylphosphatidylinositol-anchor deficient cells. Patients with aplastic anemia often evol...

BACKGROUND We investigated the efficacy of annular ligament reconstruction by suture anchor in the treatment of radial head dislocation (RHD) in children. METHOD A total of 20 RHD children nderwent annular ligament reconstruction surgery using suture anchor. Preoperative and postoperative elbow functions were evaluated according to Broberg and Morrey 100-point scale. Recovery of radial nerve ...

Malicious anchor nodes will constantly hinder genuine and appropriate localization. Discovering the malicious or vulnerable anchor node is an essential problem in wireless sensor networks (WSNs). In wireless sensor networks, anchor nodes are the nodes that know its current location. Neighboring nodes or non-anchor nodes calculate its location (or its location reference) with the help of anchor ...

   Micro-electroactive polymers have wide applications from industry to healthcare. Artificial muscles, microvalves, microswitches, haptic sensing, blood pressure and pulse monitoring are some potential applications for micro-electroactive polymers. The most advantage of micro-electroactive polymers as sensors and actuators is bio-compatibility and low power threshold for large deformations...

Did you know that some of the earliest prerequisites for data warehousing were set over 2500 years ago. It is called an anchor model since the anchors tie down a number of attributes (see picture above). All EER-diagrams have been made with Graphviz. All cats are drawn by the author, Lars Rönnbäck. 2 2 You can never step into the same river twice. 2 The great greek philosopher Heraclitus said "...

Two experiments were conducted to examine the role of three facets of numeracy (objective (ONS), subjective (SNS), and symbolic number mapping (SMap)) in three anchoring tasks (experimenter-given, self-generate, and valuation). We found that the three numeric competencies were associated with different anchoring tasks. SMap was associated with none of the three anchor tasks, while ONS consisten...